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Introduction to Cell Biology - GB335
Title: Úvod do buněčné biologie
Guaranteed by: Department of Biological and Medical Sciences (16-16150)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2024
Semester: winter
Points: 0
E-Credits: 6
Examination process: winter s.:written
Hours per week, examination: winter s.:8/4, C+Ex [HS]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech
Teaching methods: full-time
Level:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Mgr. Zuzana Svobodová, Ph.D.
Interchangeability : GB273
Is co-requisite for: GB338
Is interchangeable with: GB273
Annotation -
The main goal of Introduction to Cell Biology is to reveal to the students how the living cell works and teach them how to handle the microscope. Both will give them the background for the subjects in the upcoming years. For that, we introduce them to the structure and function of every single compartment of the cell and its chemical composition. Other areas such as cell communication, cell division, and regulation of the cell cycle are studied. Themes: Structure of prokaryotic and eukaryotic cells, membranes, membrane organelles, DNA and chromosomes, cell communication, cell cycle, reproduction of organisms.
Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Course completion requirements -

The course consists of lectures and practical exercises:


The practical exercises are concluded with the awarding of a credit, which is a necessary condition for access to the final exam
written test.


The condition for granting credit is the fulfilment of the following conditions:
1) Completion of practical exercises - microscopy and preparation of slides (1 Saturday, 5 hours)
2) Submission of the completed workbook for review


The exam consists of 40-45 questions (most of them are from lectures and a smaller part is from practical exercises).


Question types include: Single best answer, matching and picture description.
Limit for passing the test: 70% of correct answers
Rating:

excellent: 100% - 90%
very good: 89% - 80%
good: 79% - 70%

Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Literature -

Obligatory:

Last update: prepocet_literatura.php (19.09.2024)
Teaching methods -

Lectures - theory

Moodle - videos, "quizzes", "questions and answers", make-up own "glossary"

Practical classes - microscopy, observation of plant and animal cells, function of organelles, osmotic effects in plant and animal cells, cell reproduction, tissue cultures

Last update: Svobodová Zuzana, Mgr., Ph.D. (03.10.2023)
Requirements to the exam -

The student should show knowledge of Cell Biology, specifically in the following areas: 

1. Definition and general characteristics of cell
2. Structure of prokaryotic cell
3. Structure of eukaryotic cell
4. Cell nucleus
5. Structure of DNA
6. Chromosome structure in prokaryotes and viruses
7. Chromosome structure in eukaryotes
8. Replication, transcription and translation
9. Structure of living systems – water, inorganic substances, low molecular weight organic molecules
(saccharides, organic acids, amino acids, nucleotides, phospholipids)
10. Structure of living systems – high molecular weight organic molecules (polysaccharides, proteins, nucleic
acids)
11. Membrane structure
12. Cytoplasmic membrane
13. Membrane transport (carrier proteins, ion channels)
14. Mitochondria (structure, cellular respiration)
15. Chloroplasts (structure, photosynthesis)
16. Endoplasmic reticulum
17. Golgi apparatus
18. Endosomes
19. Lysosomes
20. Peroxisomes
21. Intracellular vesicular transport
22. General principles of cell communications
23. Receptors (basic characteristics, signaling cascade)
24. Ion-channel–coupled receptors
25. G-protein–coupled receptors
26. Enzyme–coupled receptors
27. Microtubules
28. Actin filaments
29. Intermediate filaments
30. Cell cycle
31. Mitosis
32. Meiosis
33. Cell cycle control system
34. Cell differentiation
35. Cell death
36. Cell stress
37. Asexual reproduction
38. Spermatogenesis
39. Oogenesis
40. Fertilization

Meiosis 33. Cell cycle control system 34. Cell differentiation 35. Cell death 36. Cell stress 37. Asexual reproduction 38. Spermatogenesis 39. Oogenesis 40. Fertilization

Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Syllabus -

Cell structure
· definition and general characteristics of cell (cell theory)
· structure of prokaryotic cell
· structure of eukaryotic cell (plant and animal)
Chemical composition of living systems
· water and inorganic substances
· low molecular weight organic molecules: saccharides, organic acids, amino acids, nucleotides,
phospholipids
· high molecular weight organic molecules: polysaccharides, proteins, nucleic acids
Nucleic acids and chromosomes I
· structure of DNA
· chromosome structure in prokaryotes and viruses
· chromosome structure in eukaryotes
Nucleic acids and chromosomes II
· replication
· transcription
· translation
Membranes I
· membrane structure
o lipid bilayer
o molecular structure of membranes – lipids, proteins, saccharides
· cytoplasmic membrane
Membranes II
· membrane transport
· carrier proteins
· ion channels and the electrical properties of membranes
Membrane organelles I
· mitochondria
o the structure
o cellular respiration – Krebs cycle, electron-transport chain, oxidative phosphorylation
· chloroplasts
o the structure
o photosynthesis – light reactions and dark reactions
Membrane organelles II
· endoplasmic reticulum
· Golgi apparatus
· endosomes
· lysosomes
· peroxisomes
· intracellular vesicular transport
o transport from the endoplasmic reticulum through the Golgi apparatus
o transport from the trans Golgi network to lysosomes
o transport into the cell from the plasma membrane: endocytosis
o transport from the trans Golgi network to the cell exterior: exocytosis
Cell communications
· general principles of cell communication
· signal molecules
· receptors
o ion-channel–coupled receptors
o G-protein–coupled receptors
o enzyme–coupled receptors
Cell division
· cell cycle - four phases (G1, S, G2, M)
· mitosis - prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis
· meiosis
Cell cycle control system
· regulation of the cell cycle
· cell differentiation
· cell death
Reproduction of organisms
asexual reproduction
characteristics
binary division, vegetative reproduction, amitosis
sexual reproduction
characteristics
gametogenesis - spermatogenesis, oogenesis, fertilization

Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Learning resources - Czech

https://intranet.faf.cuni.cz/Studijni-materialy/KBLV/

Moodle2: https://dl2.cuni.cz/ : FAF/KBLV/Kurz Buněčné biologie

Last update: Svobodová Zuzana, Mgr., Ph.D. (03.10.2023)
 
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