Pharmaceutical Chemistry II - GAF342
Title: Pharmaceutical Chemistry II
Guaranteed by: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2023
Semester: summer
Points: 0
E-Credits: 8
Examination process: summer s.:written
Hours per week, examination: summer s.:42/14, C+Ex [HS]
Capacity: unlimited / 50 (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Note: deregister from the exam date if a requisite was not fulfilled
Guarantor: prof. PharmDr. Martin Doležal, Ph.D.
Comes under: 3.ročník 2024/25 Pharmacy (EN19)
Co-requisite : GAF341
Interchangeability : GAF050
Is co-requisite for: GAF316, GAF504
Is interchangeable with: GAF050
Examination dates   SS schedule   
Annotation -
Pharmaceutical Chemistry is a specific pharmaceutical subject representing the link between chemical and biological disciplines. Its task is to provide students with a complex understanding of drug and auxiliary substance chemistry. The drugs are studied from the point of view of their rational selection and preparation, quality criteria, suitable ways of storage, structure-activity and structure-metabolism relationships, and practical usage. The brief information concerning mechanisms of drug action covered in this subject forms the basis for a more profound study of this topic in pharmacology. This subject belongs to the state final examination group of subjects.
Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Course completion requirements

Conditions to get the credit for seminars:

  • Seminars are obligatory

  • Active participation in seminars (students should read the relevant chapters before the seminar)

  • Sufficient results in the final test. 40 questions (one or more correct answers from 5 suggested). It is necessary to get 20 points. The final test will include the following pharmacodynamic groups

    1. General anesthetics

    2. Sedative-hypnotics, Anticonvulsants

    3. Antipsychotics, Antidepressants, Antiparkinsonian agents, Anti-Alzheimer agents

    4. Opioid analgesics

    5. Analgesics antipyretics, nonsteroidal anti-inflammatory agents

    6. Antitusssives and expectorants

    7. Local anesthetics, Muscle relaxants

    8. Adrenergic agents and Antiadrenergic agents

    9. Cholinergic agents and Anticholinergic agents

    10. Antihypertensives

    11. Vasodilating agents

    12. Antihyperlipidemic drugs

    13. Drugs affecting blood clotting

    14. Diuretics

    15. Steroidal hormones

    16. Antineoplastic agents

    17. Antiviral agents

    18. Antibacterial sulfonamides, Antibacterial quinolones

    19. Antituberculous agents

    20. Antibacterial antibiotics

    21. Antimycotic agents

Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Literature -

Obligatory:

  • Patrick, Graham L.. An introduction to medicinal chemistry. Oxford: Oxford University Press, 2017, 877 s. ISBN 978-0-19-874969-1.

  • Lemke, Thomas, Williams, David A. Roche, Victoria F. (eds.). Foye´s principles of medicinal chemistry. Philadelphia ; Baltimore: Lippincott Williams & Wilkins, 2013, 1500 s. ISBN 978-1-4511-7572-1.

  • Wilson, Charles Owens, Gisvold, Ole. Textbook of organic medicinal and pharmaceutical chemistry. Philadelphia: Lippincott Williams & Wilkins, 2004, 991 s. ISBN 0-7817-3481-9.

Last update: prepocet_literatura.php (19.09.2024)
Teaching methods -

lectures, seminars, practical classes, e-learning, consultations, autodidactic tests, credit tests, oral examination

Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Syllabus -

Drugs affecting the autonomic nervous system

  • Adrenergic agents
  • Antiadrenergic agents
  • Cholinergic agents
  • Anticholinergic and antispasmodic agents

Histamine and antihistamines

Drugs affecting blood and the cardiovascular system

  • Anti-arrythmic agents
  • Anticoagulants
  • Antihyperlipidemics
  • Cardiac glycosides
  • Antihypertensive agents
  • Vasodilatators
  • Plasma extenders

Drugs affecting the gastrointestinal tract and kidney

  • Drugs influencing gastric acidity
  • Adsorbents
  • Oral antidiabetic agents
  • Laxatives
  • Diuretics

Vitamines

Hormones

  • Peptide and protein hormones
  • Sex hormones and analogs
  • Corticoids
  • Prostaglandins

Antiinfective and antiinvasive agents

  • Antiseptics and disinfectants
  • Antifungal agents
  • Antiprotozoals
  • Antimalarials
  • Synthetic antibacterial agents (sulfanilamides, quinolones)
  • Antibiotics
  • Antimycobacterial agents
  • Anthelmintics
  • Antivirals
  • Antineoplastic agents
Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Learning resources -

MOODLE pro výuku 1 Univerzita Karlova

Pharmaceutical Chemistry - Practical Classes

https://dl1.cuni.cz/course/view.php?id=5363

Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Learning outcomes

   

Last update: Navrátilová Lucie, Ing. (24.02.2025)