Pharmaceutical Chemistry I - GAF341
Title: Pharmaceutical Chemistry I
Guaranteed by: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2023
Semester: winter
Points: 0
E-Credits: 4
Examination process: winter s.:
Hours per week, examination: winter s.:42/70, C [HS]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Note: deregister from the credit exam date if a requisite was not fulfilled
Guarantor: prof. PharmDr. Martin Doležal, Ph.D.
Comes under: 3.ročník 2024/25 Pharmacy (EN19)
Co-requisite : GAF339
Pre-requisite : GAF141, GAF293, GAF299
Interchangeability : GAF050
Is co-requisite for: GAF339, GAF342, GAF344, GAF244
Examination dates   WS schedule   
Annotation -
Pharmaceutical Chemistry is a specific pharmaceutical subject representing the link between chemical and biological disciplines. Its task is to provide students with a complex understanding of drug and auxiliary substance chemistry. The drugs are studied from the point of view of their rational selection and preparation, quality criteria, suitable ways of storage, structure-activity and structure-metabolism relationships, and practical usage. The brief information concerning mechanisms of drug action covered in this subject forms the basis for a more profound study of this topic in pharmacology. This subject belongs to the state final examination group of subjects.
Last update: Doležal Martin, prof. PharmDr., Ph.D. (18.02.2025)
Course completion requirements - Czech

Výuka tohoto povinného předmětu - studijního plánu 3. úseku probíhá formou přednášek, seminářů a praktických cvičení. Pro získání zápočtu je nutné absolvovat všechna praktická cvičení, předepsané semináře a úspěšně splnit zadané úkoly. Předmět je ukončen ústní zkouškou.

Last update: Doležal Martin, prof. PharmDr., Ph.D. (18.02.2025)
Literature -

Obligatory:

  • . . In Vardanyan, R. S. Hruby, Victor J.. Synthesis of essential drugs . Amsterdam ; Boston: Elsevier, 2006, s. -. ISBN 0-444-52166-6..

Last update: Doležal Martin, prof. PharmDr., Ph.D. (18.02.2025)
Teaching methods -

lectures, seminars, practical classes, e-learning, consultations, autodidactic tests, credit tests, oral examination

Last update: Doležal Martin, prof. PharmDr., Ph.D. (18.02.2025)
Syllabus -

Definition and characterization of the subject

Historical development of pharmaceutical chemistry

Sources of new drugs

Drug nomenclature

Structural factors affecting biological activity

Drug structure modifications

Physicochemical properties in relation to biological activity

Drugs affecting the central nervous system:

  • General anesthetics
  • Sedative-hypnotics
  • Anticonvulsants
  • Neuroleptics
  • Anxiolytics
  • Antidepressants
  • Psychostimulants
  • Hallucinogens
  • Antiparkinsonian agents
  • Opiate analgesics
  • Nonopiate analgesics
  • Nonsteroidal anti-inflammatory agents
  • Antiemetics
  • Antitussives
  • Expectorants

Drugs affecting the peripheral nervous system

  • Local anesthetics
  • Skeletal muscle relaxants
Last update: Doležal Martin, prof. PharmDr., Ph.D. (18.02.2025)
Learning resources -

MOODLE pro výuku 1 Univerzita Karlova

Pharmaceutical Chemistry - Practical Classes

https://dl1.cuni.cz/course/view.php?id=5363

Last update: Doležal Martin, prof. PharmDr., Ph.D. (18.02.2025)
Learning outcomes

  

Last update: Navrátilová Lucie, Ing. (24.02.2025)