Subjects

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Physical Principles of Dosage Forms - GAF308

Title:	Physical Principles of Dosage Forms
Guaranteed by:	Department of Pharmaceutical Technology (16-16210)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2024
Semester:	winter
Points:	0
E-Credits:	2
Examination process:	winter s.:written
Hours per week, examination:	winter s.:28/0, Ex [HS]
Capacity:	unlimited / unknown (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	deregister from the exam date if a requisite was not fulfilled course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	Dr. Georgios Paraskevopoulos, Ph.D.
Comes under:	3.ročník 2024/25 Pharmacy (EN19)
Co-requisite :	GAF344
Is co-requisite for:	GAF344

Examination dates WS schedule

Annotation -

Subject Physical Principles of Dosage Forms is taught in the third year of study and builds on Biophysics and Physical Chemistry. The aim of the subject is to provide comprehensive information on the basic physical principles used in formulating and stabilizing pharmaceutical forms. In particular, it describes the properties of the solid phase (active compounds and Excipients), liquid phase and dispersion (molecular, colloidal and macrodispersion) and interfacial phenomena that are related to the physical and chemical stability of pharmaceutical products. In the subject of the Physical Principles of Dosage Forms, students will also be acquainted with the basics of polymer chemistry necessary to understand the structure, properties and function of these substances in pharmaceutical formulations and modern drug delivery systems. The basic principles of pharmaceutical nanotechnologies will also be included.<br> Considering that the physical properties of materials and physical processes at the interface significantly affect the resulting quality of pharmaceutical formulations, understanding these principles is essential for further study of pharmaceutical technology and dosage forms. From this perspective, the Physical Principles of Dosage Forms can be viewed as an interdisciplinary subject with a linking function between fundamental subjects taught in the first section of study and highly specialized pharmaceutical technology.<br> Topics: Solution properties, Solid-phase, Solid-phase properties, Solubility and dissolution, Diffusion, Interfacial phenomena in pharmaceutical Systems, Pharmaceutical surfactants, Pharmaceutical polymers, Polymer systems, Rheology, Dispersion systems and their stability, Nanotechnology.

Last update: Paraskevopoulos Georgios, Dr., Ph.D. (17.07.2024)

Course completion requirements -

Written test

Last update: Paraskevopoulos Georgios, Dr., Ph.D. (17.07.2024)

Literature -

Obligatory:

Sinko, Patrick J. (ed.). Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Philadelphia: Lippicott Williams & Wilkins, 2011, 659 s. ISBN 978-1-60913-402-0.

Attwood, David Florence, Alexander T.. Physical pharmacy :. London: Pharmaceutical Press, 2008, 182 s. ISBN 978-0-85369-725-1.

Last update: prepocet_literatura.php (19.09.2024)

Syllabus -

Diffusion

Fick's laws

Permeation through polymeric membranes

Aspects of diffusion within biological systems

Solubility of gases, liquids and solids

Dissolution and factors affecting it

Drug ionization

Dialysis and drug release

Solvents for solutions and other systems

Solutions colligative properties

Properties of solids

Crystallography

Polymorfy

Crystal hydrates

Surface properties of solid phase

Wettability of solid particles

Interparticular interactions

Interfacial phenomena

liquid/liquid interphase, interfacial tension, factors affecting it

Liquid/gas interphase, surface tension, factors affecting it

Surface activity of compounds, surfactants

Structural types of surfactants

Reduction of surface and interfacial tension

HLB system

Solubilization

Micelles formulation, structural types of micelles, CMC

Disperse systems

Types of colloidal systems

Stability of colloidal systems

Pharmaceutical polymers

Polymeric systems

structure, solubility, biodegradability

Gels

Application of polymers for pharmaceutical preparations

Stimuli-responsive polymers

Basics of pharmaceutical nanotechnology

Last update: Paraskevopoulos Georgios, Dr., Ph.D. (17.07.2024)