Subjects

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Advanced Organic Chemistry - GAF229

Title:	Advanced Organic Chemistry
Guaranteed by:	Department of Organic And Bioorganic Chemistry (16-16120)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2022
Semester:	winter
Points:	0
E-Credits:	3
Examination process:	winter s.:combined
Hours per week, examination:	winter s.:0/42, C+Ex [HS]
Capacity:	unknown / unlimited (26)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Level:
Explanation:	(F 3.r.)
Note:	deregister from the exam date if a requisite was not fulfilled course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	prof. RNDr. Milan Pour, Ph.D.
Co-requisite :	GAF299
In complex pre-requisite:	GAF1002

Examination dates WS schedule

Annotation -

The subject follows up on Organic Chemistry I and II, and aims at expanding the knowledge of modern Organic Chemistry with a focus on the methods of rational design, practical synthesis and structural analysis of biologically active compounds. Topics: Modern methods of organic synthesis, Molecular modelling, Advanced structural analysis.

Last update: Pour Milan, prof. RNDr., Ph.D. (02.10.2023)

Course completion requirements -

The subject is terminated by a credit and a written exam. In order to obtain the credit, 100% attendance at seminars is required.

Last update: Pour Milan, prof. RNDr., Ph.D. (02.10.2023)

Literature -

Obligatory:

null. . In Carey, Francis A., Sundberg, Richard J.. Advanced organic chemistry . New York: Kluwer Academic ; Plenum Publishers, 2000, s. -. ISBN ..

Last update: prepocet_literatura.php (19.09.2024)

Syllabus -

Modern methods of organic synthesis

Retrosynthetic analysis
Basic principles of stereoselective synthesis
Protective groups
Catalytic reactions: metal catalysis, organocatalysis
Pericyclic reactions
Advances in heterocyclic synthesis

Molecular modelling

Introduction to molecular modelling

Advanced methods of structural analysis

Advanced techniques of NMR and MS

Last update: Pour Milan, prof. RNDr., Ph.D. (02.10.2023)

Learning outcomes

Subject Advanced Organic Chemistry follows up on the knowledge and skills acquired in the subjects: Organic Chemistry I, Organic Chemistry II

Following the completion of the subject, the students are able to use the following terms (including their commonly used abbreviations) in the correct context towards reactivity and structure elucidation of organic compounds: retrosynthesis, synthon, umpolung, steroselectivity, enantioselectivity, diastereoselectivity, organocatalysis, metal catalysis, coupling, cykloisomerazation, pericyclic reaction, protective group.

Learning Outcomes:

Based on the knowledge and skills gained, students:

Ø define the importance of knowledge of advanced methods of Organic Chemistry in drug synthesis;

Ø have a good command of contemporary developmental trends of modern Organic Chemistry;

Ø design the synthesis of a given compound;

Ø suggest suitable functional group(s) for selective transformation of a multifunctional compound;

Ø are familiar with fundamental principles of stereoselective syntheses;

Ø explain reaction mechanism of a given organic reaction, including the principles of catalytic cycles;

Ø have sound knowledge of the principal reactions, utilized in the syntheses of pharmaceutically important compounds.

Last update: Pour Milan, prof. RNDr., Ph.D. (28.03.2025)