Subjects

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Toxicology for Pharmacists - GAF158

Title:	Toxicology for Pharmacists
Guaranteed by:	Department of Pharmacology and Toxicology (16-16170)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2021
Semester:	summer
Points:	0
E-Credits:	2
Examination process:	summer s.:written
Hours per week, examination:	summer s.:28/0, Ex [HS]
Capacity:	unlimited / unknown (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Level:
Explanation:	(3.roč. F)
Note:	course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	doc. PharmDr. Jana Pourová, Ph.D.
Classification:	Pharmacy > Special Core Subjects
Comes under:	3.ročník 2024/25 Pharmacy (EN19)
Co-requisite :	GAF340

Examination dates SS schedule

Annotation -

Toxicology for pharmacists addresses toxic effects of exogenous substances, especially medicines, on the living organism. First, the general principles will be explained (basic concepts, toxicokinetics, general principles of poisoning therapy, the most important antidotes, etc.). The special toxicology will focus on drug-induced organ toxicity (cardiovascular, respiratory, hepatotoxicity, etc.), and also on the toxicity of the most common addictive substances including ethanol.

Last update: Pourová Jana, doc. PharmDr., Ph.D. (14.02.2025)

Course completion requirements -

Final test.

Last update: Pourová Jana, doc. PharmDr., Ph.D. (14.02.2025)

Literature -

Obligatory:

MOOC TOXOER [online]. Dostupné z: https://toxoer.com/

Recommended:

CURTIS D. KLAASSEN, JOHN B. WATKINS. Casarett & Doull's essentials of toxicology . New York: McGraw-Hill Medical, , s. ISBN 9780071769228.

TIMBRELL, J. Principles of biochemical toxicology . New York: Informa Healthcare, 2008, s. ISBN 978-0849373022.

Last update: Pourová Jana, doc. PharmDr., Ph.D. (14.02.2025)

Teaching methods -

Lectures.

Last update: Pourová Jana, doc. PharmDr., Ph.D. (14.02.2025)

Syllabus -

General toxicology

Toxicokinetics

General principles of poisoning therapy, antidotes

Special toxicology:

Toxicology of the cardiovascular system

Toxicology of the respiratory system

Toxicology of kidneys

Hepatotoxicity

Central stimulants and hallucinogens

Pharmaco-toxicology of ethanol

Last update: Pourová Jana, doc. PharmDr., Ph.D. (14.02.2025)

Learning resources -

TOXOER MOOC (Massive open online courses): https://toxoer.com

Last update: Pourová Jana, doc. PharmDr., Ph.D. (16.09.2022)

Learning outcomes

The course Toxicology for Pharmacists is a continuation of the course Pharmacology I and complements the simultaneous course Pharmacology II. It is based on the knowledge acquired in the courses: Human Morphology and Physiology, Biochemistry, Pathobiochemistry and Pathological Physiology for Pharmacists.

After completing the course, student understands and can use the following terms or abbreviations: toxicokinetics, toxicodynamics, antidote, LD₅₀.

Learning outcomes:

Student on the basis of acquired knowledge and skills:

understands the importance of toxicokinetics and toxicodynamics for the toxicity of xenobiotics, especially medicines;
is familiar with the most well-known antidotes, can state their indications and mechanisms of action;
can name important substances (especially medicines) that are risky for: cardiovascular system, respiratory system, liver and kidney; and explains the principles of toxicity (if known) and treatment options for these substances;
understands the toxic effects of ethanol, can describe the course and treatment of acute intoxication and chronic alcoholism and can explain the use of ethanol as an antidote;
knows the main psychostimulants and hallucinogens, their mechanisms of action, acute and long-term risks of use.

Last update: Pourová Jana, doc. PharmDr., Ph.D. (03.03.2025)