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Drug control is one of the fundamental pharmaceutical disciplines. Theoretical and practical instruction aims to guarantee the quality, safety, and efficiency of drugs, which fulfils an irreplaceable principal function of a course in pharmacy. Instruction includes not only the present editions of the Czech and European Pharmacopoeias but it is also based on other modern pharmacopoeia monographs, mainly the USP (United States Pharmacopoeia). The structure of the drug is the starting point for the determination of a suitable method for the identification.
Last update: Novotná Ladislava (19.06.2008)
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Klimeš J a kol.: Kontrola léčiv I. Praha, Karolinum 2006
Klimeš J a kol.: Kontrola léčiv II. Praha, Karolinum 2007
Český lékopis (poslední platné vydání), Praha, Grada
Roth H. J. a kol.: Pharmaceutical Chemistry, Drug Analysis. Ellis Hordwood, 1991 Last update: Novotná Ladislava (19.06.2008)
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Lectures, tutorials, practical classes. Last update: Novotná Ladislava (19.06.2008)
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Credit. Last update: Novotná Ladislava (19.06.2008)
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Lectures Structure of the drug as the starting point for the determination of analytically usable physicochemical properties Drug Identification ? Detection of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation) ? Use of physicochemical methods for the detection of drugs (spectral, separational, electrochemical methods) ? Detection of drugs by means of chemical reactions ? Group and selective reactions of individual structural types of drugs of important pharmacotherapeutic groups (analgesics-antipyretics, analgesics-anodynes, sedatives, anaesthetics, hypnotics, psychopharmaceuticals, analeptics, local anaesthetics, myorelaxants, adrenomimetics, adrenolytics, cholinomimetics, cholinolytics, antihistamines, cardiotonic glycosides, antihypertensives, vasodilators, laxatives, diuretics, vitamins, hormones, antimycotics, antimalarial agents, antibacterial sulfonamides, antibiotics, antiviral agents, anthelminthic agents) The fundamentals of drug level monitoring The principles of good laboratory practice ________________________________________ Practical Training ? Control-analytical evaluation of drugs according to the pharmacopoeia ? Identification of drugs by means of physical constants, chemical reactions, physicochemical methods ? Test for purity of drugs (chemical detection of impurities, detection of impurities, or degradation products by chromatographic and spectral methods) ? Determination of drug content (pharmacopoeial methods of quantitative evaluation of drugs)
Last update: Novotná Ladislava (19.06.2008)
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