Pharmacology II is a continuation of the pharmacology teaching in Dentistry students. Teaching is focused on special pharmacology of individual organ systems. Particularly, it is relevant to drugs affecting autonomic nervous system, cardiovascular system, haemostasis, and hormonal regulation. In addition, students will be provided an overview of basic drugs to treat diseases of GIT (with focus on peptic ulcer), respiratory tract (with focus on asthma) and CNS (hypno-sedative drugs, anxiolytics, antidepressants, and antipsychotics). Students will be thought general aspects of chemotherapy of viral, mycotic, and oncological diseases and basic classes of drugs will be highlighted. Practical teaching is oriented on analysis of the theoretical knowledge in discussion with the responsible teacher and solving of real pharmacotherapeutic situations and cases.
Entry requirements
Last update: Hana Kalhousová (06.02.2024)
Prerequisites: Physiology II
Aim of the course
Last update: Hana Kalhousová (06.02.2024)
Outcomes (Subject Pharmacology II):
Student will receive theoretical knowledge in special pharmacology of main organ systems with gross impact on the whole organism (autonomic nervous system, cardiovascular system, haemostasis, and hormonal regulation)
Student will obtain a competency in overview of drugs used to treat diseases of GIT (with focus on peptic ulcer), respiratory tract (with focus on asthma) and CNS (hypno-sedative drugs, anxiolytics, antidepressants, and antipsychotics).
Students will obtain basic understanding to general aspects of chemotherapy of viral, mycotic, and oncological diseases and basic classes of drugs in this area
Student will be able to discuss basic pharmacological properties of given drugs, their use in clinical practice and will have a competency to employ the theoretical knowledge to solve particular pharmacotherapeutic issues in clinical practice.
Requirements to the exam
Last update: Hana Kalhousová (06.02.2024)
Conditions for granting credit in pharmacology:
a) Attendance at classes
Participation in seminars and practical exercises is mandatory. Only one absence is acceptable (the reason does not need to be documented); late arrivals to classes will also be counted as absences if they are significant. In case of two absences, the student will be examined in detail from topics of both missed practical exercises in order to receive credit. Due to three or more absences, the student will be tested for the entire semester in order to receive credit. In the latter case, it is also necessary to provide official reasons and appropriate confirmations (e.g., from a doctor, from the office, etc.).
b) Worksheets
During the semester, in practical courses and seminars, students solve model clinical situations presented through worksheets or by the teacher's oral assignment. Students must submit written solutions to these assignments upon request.
c) Knowledge
At each practical course, a graded check of students' knowledge takes place in written or oral form. The average of all gradings (marks) received during the semester must be less than or equal to 3.00 to receive the credit (absences have no impact on the average). If a student fails to achieve required average mark (i.e., average > 3.00) - the student will be examined in the scope of the entire semester.
d) In the event of a forced transition to online teaching (e.g. due to pandemic conditions)
Practical teaching will take place in a distance form through MS TEAMS using materials provided in MOODLE LFHK. Students will be required to have the cameras ready and switched on, if not given otherwise. Continuing (repeated) technical problems on the student side will be considered an absence. The main content of the practical teaching will be a moderated discussion and the solution of examples from clinical practice using written or oral assignments. Knowledge testing will take place continuously online orally, or in the form of a face-to-face credit test when the epidemiological situation allows it.
Final exam:
Credits from the subjects Pharmacology I and II are required for taking the exam. The exam starts with a test. The test is an integral part of every attempt, and its result is an essential part of the classification. The test is focused on basic knowledge of individual topics of the subject and determines an overview of the field. If the student manages to achieve a result of 1 or 1- in the exam test and at the same time has an average grade (mark) from all the tests in both the summer and winter semester of 2.00 or less (assessed in each semester separately), he/she will draw only one question from general pharmacology. If this condition is not met, the student will draw one question from general pharmacology and one from special pharmacology. If the result from the test is worse than 3 (i.e., 3- or 4) on the first attempt, the exam is terminated with a "failed" result. If the test result is worse than 3 during the second or third attempt, it is possible to advance to the oral part of the exam, but it is necessary to give a convincing performance in oral part.
Syllabus
Last update: Hana Kalhousová (06.02.2024)
Teachers
Prof. Stanislav Mičuda, M.D., Ph.D.
Jolana Schreiberová, M.D., Ph.D.
Assoc. Prof. PharmDr. Martin Sterba, Ph.D.
Assoc. Prof. Ing. Jaroslav Chládek, Ph.D.
PharmDr. Olga Lenčová, Ph.D.
Lectures
Autonomic nervous system - introduction and cholinergic agonists and antagonists.
Autonomic nervous system - adrenergic agonists and antagonists.
CNS acting drugs - hypnosedatives, basics of pharmacological treatment of depression, anxiety and psychotic disorders.
Pharmacology of hormones - diabetes and oral antidiabetics, sexual hormones and oral contraceptives.
Practical courses & seminars
1. Autonomic nervous system - cholinergic agonists and antagonists, skeletal muscle relaxants. 1.1. Analysis of case studies. 1.2. Test. 2. Autonomic nervous system - adrenergic agonist and antagonists, autonomic ganglia. 2.1. Analysis of case studies. 2.2. Test. 3. Drugs influencing respiratory and GIT systems. 3.1. Mikrolesson. 3.2. Analysis of case studies. 3.3. Test. 4. Drugs with positive inotropic action, RAAS drugs. 4.1.Seminar, analysis of case studies
4.2. Diuretics – microlesson. 4.3. Test. 5. Pharmacological treatment of hypertension, ischemic heart disease and heart failure. 5.1. Seminar on the above given topic – moderated discussion and analysis of case studies. 5.2. Test. 6. Histamine, antihistaminics. Drugs affecting hemostasis. 6.1. Mikrolesson. 6.2. Seminar on the above given topic – moderated discussion and analysis of case studies. 6.3. Test. 7. General aspects of anticancer therapy, antiviral and antifungal therapy and selected strategies and classes of drugs. 7.1. Mikrolesson. 7.2. Seminar on the above given topic – moderated discussion and analysis of case studies. 7.3. Test. 8. Hormones - antidiabetics and glucocorticoids. 8.1. Seminar on the above given topic – moderated discussion and analysis of case studies. 8.2. Test. 8.3. Credit granting to eligible students.
Literature
Last update: Hana Kalhousová (06.02.2024)
Compulsory literature
Whalen K et al: Lippincott´s Illustrated Reviews: Pharmacology, 2018, 7th ed., Lippincott Williams and Wilkins, ISBN 978-1496384133
Recommended literature
Ritter JM et al: Rang and Dales: Pharmacology. 9th ed., Elsevier, 2019. ISBN 978-0702074486
