Cytogenetics – View from Laboratory Practice - EAV030X01

• Title: Cytogenetics – View from Laboratory Practice
• Guaranteed by: Ústav biologie (14-30)
• Faculty: Faculty of Medicine in Pilsen
• Actual: from 2021
• Semester: summer
• Points: 2
• E-Credits: 2
• Examination process: summer s.:
• Hours per week, examination: summer s.:4/0, C [HS]
• Extent per academic year: 4 [hours]
• Capacity: unknown / unknown (unknown)
• Min. number of students: 3
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Teaching methods: full-time
• Note: course can be enrolled in outside the study plan
• Guarantor: doc. RNDr. Pavel Dvořák, Ph.D.
• Comes under: Volitelné předměty, 2. ročník AVSEOB; Volitelné předměty, 2. ročník AVSEOB20; Volitelné předměty, 2. ročník AZUB18; Volitelné předměty, 3. ročník AVSEOB; Volitelné předměty, 3. ročník AVSEOB20; Volitelné předměty, 3. ročník AZUB.L.; Volitelné předměty, 4. ročník AVSEOB20; Volitelné předměty, 5. ročník AVSEOB
• Incompatibility : EA0104030
• Interchangeability : EA0104030
• Is incompatible with: EA0104030
• Is interchangeable with: EA0104030

Annotation

This seminar extends the basic information about cytogenetics taught during the compulsory biology seminar in the first year. After a brief summary of the historical milestones in the cytogenetic field and an overview of the use of cytogenetic methods in present medicine, relevant examples from the areas of prenatal, postnatal and cancer cytogenetics are discussed.

Last update: Buriánková Martina, Mgr. (16.05.2018)

Literature

I. D. Young: Medical genetics, Oxford University Press, 2010.

D. E. Rooney: Human Cytogenetics - Constitutional Analysis - Malignancy and Acquired Abnormalities, Oxford University Press, 2001.

J. L. Huret et al.: Atlas of Genetics and Cytogenetics in Oncology and Haematology [online]. http://atlasgeneticsoncology.org/

Last update: Buriánková Martina, Mgr. (16.05.2018)

Requirements to the exam

Aktivní účast.

Last update: Buriánková Martina, Mgr. (25.10.2019)

Syllabus

Morgan's fly room; Tjio and Levan – the correct number of chromosomes in humans; Lejeune and Jacobs - supernumerary copy of chromosome 21 in Down syndrome patients; Nowell and Hungerford – Philadelphia chromosome and leukemia; methodology of chromosome karyotyping; G and R banding; FISH and CGH methods; Denver and Paris cytogenetic nomenclature; ISCN and common chromosomal abnormalities; amniocentesis and prenatal screening of chromosomal abnormalities; chorionic villi sampling; microdeletion and microduplication syndromes; oncocytogenetics; the story of Gleevec; biological therapy in cancer.

Last update: Buriánková Martina, Mgr. (16.05.2018)