Immunology - EA0906520

• Title: Immunology
• Guaranteed by: Ústav imunologie a alergologie (14-520)
• Faculty: Faculty of Medicine in Pilsen
• Actual: from 2022
• Semester: summer
• Points: 2
• E-Credits: 2
• Examination process: summer s.:
• Hours per week, examination: summer s.:0/1, C+Ex [HT]
• Capacity: unknown / unknown (unknown)
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Teaching methods: full-time
• Note: deregister from the exam date if a requisite was not fulfilled
• Guarantor: prof. MUDr. Petr Panzner, CSc.
• Co-requisite : EA0903015, EA0904011
• Is co-requisite for: EA0908360, EA0208024, EA0907380, EA0908023, EA0907330, EA0908310

Annotation

English

In this subject, the student acquires basic knowledge about the structure and function of the immune system, acquaints with pathogenesis, clinical manifestations, and treatment of the most important immunopathological diseases.

Last update: Nováková Lenka (14.11.2017)

Czech

V tomto předmětu získá student základní znalosti o struktuře a funkci imunitního systému, seznámí se s patogenezí, klinickými projevy a léčbou nejvýznamnějších imunopatologických chorob.

Last update: Nováková Lenka (14.11.2017)

Literature

 

Recommended literature:

Abbas A. K., Lichtman A. H. H., Pillai S.: Basic Immunology: Functions and Disorders of the Immune Systém. Elsevier Health Sciences, 2012

Supplementary literature:

Doan T., Melvold R., Viselli S., Valtenbaugh C: Immunology. Lippincott Williams & Wilkins, (2nd Edition), 2012

Delves P.J., Martin S.J., Burton D.R., Roitt I.M.: Roitt's Essential Immunology (13th Edition), Wiley-Blackwell, 2017

Weaver C., Murphy K.: Jeneway's Immunobiology (9th Edition), Garland Science, Taylor & Francis Group, LLC, 2017

Last update: Nováková Lenka (15.11.2017)

Requirements to the exam

Course conditions:
The course is finished by credit and examination.

Conditions for obtaining the credit:
Teaching is conducted in the form of seminars. Active participation in the seminars is necessary to obtain the credit, one absence is allowed.

Conditions for passing the exam:
1. Successful passing a computer test.
2. Answering two oral questions.

 

 Exam questions:

1. The immune system and its importance for homeostasis. Antigen.
    Mechanisms of the immune system and their cooperation.

2. Component parts of the immune system (organs, cells, substances) and their function.

3. Non-specific cellular and humoral immune mechanisms (characteristics, function).

4. Specific cellular and humoral immune mechanisms (characteristics, function).

5. Phagocytosis (phagocytes, their functions, and importance).

6. Complement, pathways of activation, biological significance.

7. Basophils and mast cells and their role in the immune reactions.

8. Immune mechanisms of inflammation (local and systemic reaction).

9. Natural killer cells, their characteristics, and their function. Interferons.

10. HLA system  (classes, polymorphism, typing).

11. Binding of peptides to MHC. Antigen presentation (function, purpose).

12. T-lymphocytes (ontogenesis, selection, surface markers, subpopulations, functions). TCR.

13. Th1 based immune reaction.

14. Th2 based immune reaction.

15. Tc based immune reaction.

16. Physiological mechanisms of regulation of the immune system.
      Cytokines (classification according to the function).

17. B-lymphocytes - ontogenesis, surface markers, function. Ontogenesis of antibody production.    

18. Immunoglobulins (structure, classes). Genetic background of immunoglobulin production.
      Anti-idiotypes.

19. Immunoglobulins (functions of different isotypes).

20. Antibodies based immune reaction (primary, secondary).

21. Mucous and cutaneous immune system
      (Barrier functions of the human body and defense mechanisms).

22. External regulation of immune response (possibilities, purposes).

23. Defense against extracellular pathogens (bacteria and unicellular parasites).

24. Defense against intracellular pathogens (bacteria, fungi, and unicellular parasites).

25. Anti-viral defense.

26. Defense against multicellular parasites.

27. Tumor immunology - tumor antigens, mechanisms of defense.

28. Alloimmune reaction. Types of transplantations and immunological examination before
      transplantation. Immunologically privileged tissues.

29. Types of graft rejection and their mechanisms. GvH disease. Principles of materno-foetal tolerance.
      Rh incompatibility

30. IgG and IgM based immunopathological reaction (reaction of hypersensitivity type II).

31. Immunocomplex based immunopathological reaction (reaction of hypersensitivity type III).

32. Acquired immunodeficiencies - causes, mechanisms involved. AIDS.

33. Primary immunodeficiencies - clinical manifestations, examples.

34. Hereditary angioedema (pathophysiology, clinical manifestations, treatment).

35. Examples of systemic autoimmune diseases. Significance of autoantibodies.

36. Examples of organ-specific autoimmune diseases and organoleptic autoimmune diseases.
      Significance of autoantibodies.

37. Immunopatological reaction type IV (delayed-type). Cutaneous and mucous contact allergy.

38. IgE based immunopathological reaction (type I, atopy).

39. Allergens. Allergic diseases - causes, symptoms, and diagnostics.

40. Anaphylaxis (causes, symptoms, and treatment).

41. Examples of diseases based on immunopathological reaction type I. Treatment.

42. Drug allergy.

 

Last update: Nováková Lenka (18.05.2020)

Syllabus

Immunology - 3^rd year - Dentistry                                                                        SS 2023/2024

Seminars take place in the seminar room of the Department of Immunology and Allergology, entrance C, 2^nd floor, room No 345, 9.00 – 10.40 

 

23. 2. 2024          Mgr. Ochotná Jitka

1. The immune system and its importance for homeostasis. Antigen.
    Mechanisms of the immune system and their cooperation.

2. Component parts of the immune system (organs, cells, substances) and their function.

3. Non-specific cellular and humoral immune mechanisms (characteristics, function).

4. Specific cellular and humoral immune mechanisms (characteristics, function).

5. Phagocytosis (phagocytes, their functions and importance).

6. Complement, pathways of activation, biological significance.

7. Basophils and mast cells and their role in the immune reactions.

 

8. 3. 2024            Mgr. Ochotná Jitka

8. Natural killer cells, their characteristics, and their function. Interferons.

9. HLA system  (classes, polymorphism, typing).

10. Binding of peptides to MHC. Antigen presentation (function, purpose).

11. T-lymphocytes (ontogenesis, selection, surface markers, subpopulations, functions). TCR.

12. Th1 based immune reaction.

13. Th2 based immune reaction.

14. Tc based immune reaction.

 

22. 3. 2024          MUDr. Vachová Martina, Ph.D.

15. B-lymphocytes - ontogenesis, surface markers, function. BCR. Ontogenesis of antibody production.    

16. Immunoglobulins (structure, classes). Genetic background of immunoglobulin production.
      Class switching. Anti-idiotypes.

17. Immunoglobulins (functions of different isotypes).

18. Antibodies based immune reaction (primary, secondary).

19. Mucous and cutaneous immune system (Barrier functions of the human body and defense mechanisms).

20. External regulation of immune response (possibilities, purposes).

 

5. 4. 2024            Mgr. Ochotná Jitka

21. Immune mechanisms of inflammation (local and systemic reaction).

22. Physiological mechanisms of regulation of the immune system. Cytokines (classification

      according to the function).

23. Defense against extracellular pathogens (bacteria and unicellular parasites).

24. Defense against intracellular pathogens (bacteria, fungi and unicellular parasites).

25. Anti-viral defense.

26. Defense against multicellular parasites.

 

19. 4. 2024          Mgr. Ochotná Jitka

27. Tumor immunology - tumor antigens, mechanisms of defense.

28. Alloimmune reaction. Types of transplantations and immunological examination before
      transplantation. Immunologically privileged tissues.

29. Types of graft rejection and their mechanisms. GvH disease. Principles of materno-foetal tolerance.
      Rh incompatibility

30. IgG and IgM based immunopathological reaction (reaction of hypersensitivity type II).

31. Immunocomplex based immunopathological reaction (reaction of hypersensitivity type III).

 

3. 5. 2024            MUDr. Liška Martin, Ph.D.

32. Acquired immunodeficiencies - causes, mechanisms involved. AIDS.

33. Primary immunodeficiencies - clinical manifestations, examples.

34. Hereditary angioedema (pathophysiology, clinical manifestations, treatment).

35. Examples of systemic autoimmune diseases. Significance of autoantibodies.

36. Examples of organ-specific autoimmune diseases and organoleptic autoimmune diseases.
      Significance of autoantibodies.

 

17. 5. 2024          prof. MUDr. Panzner Petr, CSc.

37. Immunopatological reaction type IV (delayed-type). Cutaneous and mucous contact allergy.

38. IgE based immunopathological reaction (type I, atopy).

39. Allergens. Allergic diseases - causes, symptoms, and diagnostics.

40. Anaphylaxis (causes, symptoms, and treatment).

41. Examples of diseases based on immunopathological reaction type I. Treatment.

42. Drug allergy.

 

 

Last update: Nováková Lenka (17.01.2024)

Learning resources

Course of Immunology and allergology  in MOODLE:

https://lms.lfp.cuni.cz/course/view.php?id=318

Last update: Nováková Lenka (25.02.2021)