Clinical Biochemistry - EA0110126

• Title: Clinical Biochemistry
• Guaranteed by: Ústav klinické biochemie a hematologie (14-540)
• Faculty: Faculty of Medicine in Pilsen
• Actual: from 2023
• Semester: winter
• Points: 2
• E-Credits: 2
• Examination process: winter s.:
• Hours per week, examination: winter s.:30/0, C+Ex [HS]
• Extent per academic year: 6 [days]
• Capacity: unknown / unknown (unknown)
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: not taught
• Language: English
• Teaching methods: full-time
• Additional information: http://lms.lfp.cuni.cz/course/view.php?id=170
• Note: deregister from the exam date if a requisite was not fulfilled
• Guarantor: MUDr. Daniel Rajdl, Ph.D.; prof. MUDr. Jaroslav Racek, DrSc.
• Interchangeability : EAP0105540
• Is co-requisite for: EA0112038, EA0112033, EA0112029, EA0112023, EA0112019, EA0112024
• Is incompatible with: EAP0105540
• Is interchangeable with: EAP0105540

Annotation

Seminars take place in the new seminar room of our institute - University Hospital Lochotin, entrance B, 2nd floor, next to the elevators.

Medical students will gain knowledge of the organization and work of a clinical laboratory. They will become acquainted with problems of preanalytical influences on the results of laboratory examinations, methods for estimation of reference limits, and questions of "evidence-based medicine" (i.e., problems of diagnostic sensitivity and specificity, concept of a risk factor, etc.). The main outcome is to help students to understand indication and interpretation of the most common laboratory tests. The classes are interactive, focusing on proper understanding of problems rather than memorizing knowledge. Some classes begin with readiness quiz to ensure some basic knowledge before starting more complicated topics. The classes are supported by e-learning course: http://lms.lfp.cuni.cz/course/view.php?id=170 where you can find more information and study materials (texts, presentations, study quizzes).

Last update: Rajdl Daniel, MUDr., Ph.D. (01.02.2017)

Literature

• Course Clinical biochemistry, accessible on-line from WWW: http://lms.lfp.cuni.cz/course/view.php?id=170 (login via CAS), cited on 1.2.2017
• Beckett, G.J., Walker, S.W., Rae, P., Ashby,P.: Lecture Notes Clinical Biochemistry.
  8^thEdition, Wiley-Blackwell, Oxford, London, Edinburgh etc., 2010, 344 pp. ISBN: 978-1-4051-9305-4
  9^thEdition, Wiley-Blackwell, Oxford, London, Edinburgh etc., 2013, 344 pp. ISBN: 9781118272114
• also accessible via Ebrary (ligin with CAS): http://site.ebrary.com/lib/cuni/detail.action?docID=10748680  [cited on 2.5.2015]

Last update: Rajdl Daniel, MUDr., Ph.D. (01.02.2017)

Requirements to the exam

Attening seminars (1 absence allowed) ; you have to successfully passed 5 of 6 credit quizzes (see literature for direct access to the course, where questions from these quizzes are) to receive credit. You don´t need to wear spacial clothes (white coat ...) during seminars. We recommend to have a smartphone or laptop and you should be prepaired according to instructions that you will receive by e-mail one week before your teaching block. The exam is in the form of a complex written quiz with standardized points. Minumum points to pass is 65 %.

Last update: Rajdl Daniel, MUDr., Ph.D. (02.09.2020)

Syllabus

More accurate learning outcomes can be found in the e-learning course.

1. Preanalytical influences on laboratory tests.
2. Reference values, methods of their determination.
3. Analytical properties of laboratory methods, quality control.
4. Diagnostic sensitivity and specificity, their relationship, laboratory screening.
5. Basic examination of urine.
6. Non-protein nitrogen substances.
7. Electrophoresis of serum proteins, electrophoretic types.
8. Significance of determination of serum proteins.
9. Na, K, Cl - clinical significance of determination.
10. Ca, P, Mg - clinical significance of determination.
11. Trace elements.
12. Vitamins.
13. Thyroid hormones.
14. Hormones of hypothalamus and pituitary gland.
15. Hormones of adrenal cortex.
16. Metabolic acidosis.
17. Metabolic alkalosis.
18. Respiratory disorders of acid-base balance.
19. Combined disorders of acid-base balance.
20. Osmolality - clinical significance.
21. Serum lipids: metabolism and relationship to atherogenesis.
22. Risk factors of atherosclerosis (with exception of lipids).
23. Laboratory examinations of patients with liver diseases.
24. Laboratory diagnostics of jaundice.
25. Laboratory markers of bone metabolism.
26. Functional tests of kidneys.
27. Laboratory examination of gastrointestinal tract.
28. Laboratory diagnostics of diabetes mellitus.
29. Laboratory control of diabetes mellitus.
30. Laboratory diagnostics of myocardial infarction.
31. Laboratory markers of malignancies (tumour markers).
32. Cytochemical examination of cerebrospinal fluid.
33. Hereditary metabolic diseases - laboratory diagnostics.
34. Laboratory examinations of patients with urinary stones.
35. Laboratory examinations in pregnancy.
36. Peculiarities of laboratory examinations of infants.
37. Basic principles of toxicological examinations.

Last update: Rajdl Daniel, MUDr., Ph.D. (04.12.2020)

Learning resources

Supplementary online course is at https://lms.lfp.cuni.cz/course/view.php?id=172

Last update: Rajdl Daniel, MUDr., Ph.D. (25.09.2020)