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Course, academic year 2024/2025
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Cell - DA1101001
Title: Cell
Guaranteed by: Department of Biology and Medical Genetics (13-716)
Faculty: Second Faculty of Medicine
Actual: from 2022
Semester: winter
Points: 3
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:28/0, C+Ex [HS]
Extent per academic year: 14 [weeks]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Guarantor: prof. Ing. Zdeněk Sedláček, DrSc.
Teacher(s): RNDr. Šárka Bendová, Ph.D.
MUDr. Alžběta Blanková
MUDr. Petra Dvořáková
Mgr. Miroslava Hančárová, Ph.D.
RNDr. Eduard Kočárek, Ph.D.
MUDr. Matej Kohutiar, Ph.D.
RNDr. Tomáš Kučera, Ph.D.
Mgr. Hana Lukšanová, Ph.D.
Mgr. Darina Prchalová, Ph.D.
MUDr. Kamila Procházková, Ph.D.
MUDr. Pavel Roštok
prof. Ing. Zdeněk Sedláček, DrSc.
MUDr. Jiří Uhlík, Ph.D.
MUDr. Andrea Vajsová
Is pre-requisite for: DA1103337, DA1103446, DA1103040, DA1104339
Annotation - Czech
Jde o povinný studijní předmět, který patří mezi základní teoretické předměty profilujícího základu. Jeho absolvováním student získá základní znalosti a dovednosti v oblasti biochemie, buněčné biologie a genetiky, které jsou nezbytným předpokladem pro další úspěšné studium ve specializovaných předmětech a ve vyšších ročnících. Jedním z hlavních cílů předmětu je také vyrovnat různé úrovně znalostí těchto základních oborů, se kterými přicházejí studenti z různých středních škol. V rámci předmětu se student naučí popsat základy struktury a funkce živých systémů na úrovních molekul, organel a buněk, a pochopí přesah těchto principů do úrovní tkání, orgánů a celých organismů.
Last update: Čechová Jana, Mgr. (02.08.2021)
Course completion requirements - Czech

Rules for successful study of the subject Cell

During the semester

• Attendance at lectures is voluntary, but strongly recommended. Presentations available electronically do not and cannot replace your personal participation at the lectures.

• Lecture presentations, other materials (syllabus, exam questions, literature etc.) and up-to-date information on the subject are in MS Teams (login: university_personal_No@cuni.cz, team code: 1jcrpl0). In case of technical problems with MS Teams please contact sarka.bendova@lfmotol. cuni.cz.

• Consultations are possible preferably by asking the question via e-mail to the teacher of the respective lecture. Questions (anonymously) and answers will also be placed in MS Teams to be available to all.

• In lectures No. 5, 10 and 14, students will write an optional multiple-choice test with 10 questions covering the topics presented in lectures indicated in the syllabus. The results of each of these three tests will be evaluated 0-10 points. Attempts to cheat will be punished by evaluating the test 0 points (this applies also to credit and exam tests). To learn from the mistakes, students can ask within seven calendar days after sitting the test via e-mail to the teacher responsible for the respective test for a review of the test and consultation.

Credit

• The total gain from the three tests during the semester will thus be 0-30 points, and students will obtain the credit automatically if they achieve at least 16 points for these tests.

• Students who gain 0-15 points will sit a comprehensive multiple-choice credit test with 10 questions covering all themes. The test will be evaluated 0-10 points. Credit will be granted to those who gain at least six points. The first possibility to sit the credit test will be in the first week of the winter semester exam period. Students are strongly advised to take the first attempt in this week. In case of failure it will be possible to repeat the credit test twice at dates announced for the remaining weeks of this exam period. After the end of this exam period it will no longer be possible to obtain the credit.

• Students must bring their ISIC or another ID card to be admitted to write the credit test or sit the exam.

Exam

• The condition for taking the exam is a granted credit.

• Students will have three attempts to sit the exam. The regular and first retake attempts will have the format of a multiple-choice test with 15 questions. The test will be evaluated 0-15 points. The final result of the exam will depend on the point yield: "výborně" (15-13 points), "velmi dobře" (12-11 points), "dobře" (10-8 points), or "nevyhověl/a" (7-0 points). The second retake attempt (or the last possible attempt in the given academic year) will have the format of a commission oral exam during which the student will draw and answer a triplet of questions.

• To learn from the mistakes in credit and exam tests students can ask sarka.bendova@lfmotol.cuni.cz within seven calendar days after sitting the test for a review of the test.

• The exam period is dedicated to exams and students are strongly advised to take at least the first attempt during this period. After the end of the exam period there will be only one additional date in May and one in September. Failure to take an attempt in the winter term exam period therefore means that the student has only two attempts left in the respective academic year.

Last update: Dimitriou Alena, Bc. (30.09.2024)
Literature - Czech

Literature for the subject Cell

Compulsory textbooks:

  • Your notes from the lectures and presentations and other materials from classes archived in MS Teams
  • Alberts, B. et al.: Essential Cell Biology. 5th Ed., W. W. Norton & Company, 2019 – only chapters 1-7, 13, 14
  • Mescher, A. L.: Junqueira’s Basic Histology: 17th Ed. McGraw-Hill, 2023
  • Pritchard D.J., Korf B.R.: Medical Genetics at a Glance. 3rd Edition. Wiley-Blackwell, 2013
  • Sadler, T. W.: Langman's Medical Embryology. 15th ed., Wolters Kluwer, 2023

Recommended textbooks:

  • Bolsover, S.R. et al.: Cell Biology: A Short Course. 3rd Edition, Willey-Blackwell, 2011
Last update: Dimitriou Alena, Bc. (30.09.2024)
Requirements to the exam - Czech

1 Buňka/Cell

Buňka a její součásti

Glykolýza a glukoneogeneze

Posttranslační úpravy

Cell and its components

Glycolysis and gluconeogenesis

Posttranslational modifications

__________________________________________________________

2 Buňka/Cell

Struktura biologické membrány

Citrátový cyklus

Genetický kód a jeho vlastnosti

Structure of biological membrane

Citric acid cycle

Genetic code and its properties

__________________________________________________________

3 Buňka/Cell

Membránový transport

Struktura a funkce sacharidů

Regulace genové exprese

Membrane transport

Structure and function of carbohydrates

Regulation of gene expression

__________________________________________________________

4 Buňka/Cell

Buněčná signalizace a adheze

Močovinový cyklus

Možnosti vzniku mutací

Cell signalization and adhesion

Urea cycle

Origin of mutations

__________________________________________________________

5 Buňka/Cell

Mitochondrie

Metabolizmus mastných kyselin

Klasifikace mutací

Mitochondria

Metabolism of fatty acids

Classification of mutations

__________________________________________________________

6 Buňka/Cell

Ribosomy a další nemembránové organely

Propojení metabolických drah

Základní typy reparace DNA

Ribosomes and other non-membranous organelles

Integration of metabolism and metabolic pathways

Basic types of DNA repair

__________________________________________________________

7 Buňka/Cell

Granulární endoplasmatické retikulum

Základní strategie metabolizmu buňky

Základní rozdíly mezi prokaryotickou a eukaryotickou buňkou

Rough endoplasmic reticulum

Basic strategy of cell metabolism

Basic differences between prokaryotic and eukaryotic cell

__________________________________________________________

8 Buňka/Cell

Hladké endoplasmatické retikulum

Funkce ATP a energetické spřažení biochemických reakcí

Genom a karyotyp člověka

Smooth endoplasmic reticulum

Function of ATP and energy coupling of biochemical reactions

Human genome and karyotype

__________________________________________________________

9 Buňka/Cell

Golgiho komplex

Katabolizmus a anabolizmus

Struktura a modifikace chromatinu

Golgi complex

Catabolism and anabolism

Chromatin structure and modifications

__________________________________________________________

10 Buňka/Cell

Lysosomy a peroxisomy

Energie a rovnováha

Struktura lidského genu

Lysosomes and peroxisomes

Energy and equilibrium

Structure of a human gene

__________________________________________________________

11 Buňka/Cell

Mikrofilamenta

Struktura a funkce enzymů

Typy RNA v lidské buňce a jejich funkce

Microfilaments

Structure and function of enzymes

Types of RNA in human cells and their functions

__________________________________________________________

12 Buňka/Cell

Intermediální filamenta

Princip enzymové katalýzy

Typy variant v lidském genomu

Intermediate filaments

Mechanisms of enzyme catalysis

Types of variants in human genome

__________________________________________________________

13 Buňka/Cell

Mikrotubuly

Metabolizmus proteinů

Mechanismy ovlivnění fenotypu genetickou variabilitou

Microtubules

Protein metabolism

Mechanisms how phenotype is influenced by genetic variability

__________________________________________________________

14 Buňka/Cell

Centriol

Struktura a funkce nukleových kyselin

Definice života a základní znaky živých organismů

Centriole

Structure and function of nucleic acids

Definition of life and basic features of living organisms

__________________________________________________________

15 Buňka/Cell

Cytoplasmatické inkluse

Struktura a funkce aminokyselin

Základní procesy v evoluci organismů a biodiverzita života na planetě

Cytoplasmic inclusions

Structure and function of amino acids

Basic processes in the evolution of organisms and biodiversity of life on the planet

__________________________________________________________

16 Buňka/Cell

Jádro buněčné

Struktura a funkce lipidů

Centrální dogma molekulární biologie

Nucleus

Structure and function of lipids

Central dogma of molecular biology

__________________________________________________________

17 Buňka/Cell

Buněčný cyklus a mitotické dělení

Dýchací řetězec

Translace a struktury a enzymy, které se na ni podílejí

Cell cycle and mitotic division

Respiratory chain

Translation and structures and enzymes involved

__________________________________________________________

18 Buňka/Cell

Meiotické dělení

Struktura a funkce proteinů

Replikace DNA a enzymy, které se na ní podílejí

Meiotic division

Structure and function of proteins

DNA replication and enzymes involved

__________________________________________________________

19 Buňka/Cell

Fertilizace a rýhování vajíčka

Přehled energetického metabolizmu

Transkripce a enzymy, které se na ní podílejí

Fertilization and cleavage of oocyte

Energy metabolism overview

Transcription and enzymes involved

__________________________________________________________

20 Buňka/Cell

Blastocysta a její implantace

Regulace enzymové katalýzy

Posttranskripční úpravy

Blastocyst and its implantation

Regulation of enzyme catalysis

Posttranscriptional modifications

__________________________________________________________

Last update: Dimitriou Alena, Bc. (30.09.2024)
 
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