SubjectsSubjects(version: 964)
Course, academic year 2024/2025
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Clinical Biochemistry - DA0108390
Title: Clinical Biochemistry
Guaranteed by: Department of Medical Chemistry and Clinical Biochemistry (13-352)
Faculty: Second Faculty of Medicine
Actual: from 2024
Semester: winter
Points: 2
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:0/30, C+Ex [HT]
Extent per academic year: 1 [weeks]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Is provided by: DA1108390
Guarantor: prof. MUDr. Richard Průša, CSc.
Teacher(s): prof. MUDr. Richard Průša, CSc.
Classification: Medicine > Clinical Disciplines
Pre-requisite : DA0105341, DA0105439
Is pre-requisite for: DA0110369
Annotation
Clinical biochemistry courses is based on analysis of case reports, lectures and seminars. Teaching the right and proper indication of biochemical tests and interpretation of the results is emphasized.
Last update: HABET (15.10.2012)
Course completion requirements

1. 100% presence

Participation in the course is compulsory in full length. Exceptionally, upon agreement with the head of the department, the relevant teaching topic can be attended with another group if the capacity permits. Quite exceptionally, upon agreement, a certificate of the doctor can be recognized.

2. Successful completion of the test

Evaluation and test structure: This is a written test consisting of 10 questions. The test is assembled by a random selection using a special computer programme Edubase. The student has to achieve at least 60% success in the test. For each question there is one or more correct answers from a selection of different number of answers. Each question is evaluated as a whole; only those test questions that have all the correct answers checked and not the incorrect answers checked are recognized as correctly answered.

Last update: Čechová Jana, Mgr. (07.10.2019)
Literature
Marshall, W. J.: Clinical chemistry : Mosby, 3rd, 4th, 5th, 6th ed. (B)

Last update: HABET (24.01.2014)
Requirements to the exam

The subsequent condition for admission to the exam is the credit awarded.

This is an oral exam, in which the student randomly pulls a patient´s sheet with biochemical results. The essence of the exam is the interpretation of these results and differential diagnostic balance.

The topics of the laboratory results sheets are in accordance with the “Examination circuits” presented on the website of the Department of Medical Chemistry and Clinical Biochemistry and the contents of lectures and seminars of the subject “Clinical biochemistry”.

Clinical biochemistry course / topics for examination

1) C – reactive protein, high sensitive CRP

2) Thyroid hormones

3) Proteins of acute phase (positive and negative reactants), procalcitonin

4) Biological and analytical variability

5) Tumour markers

6) Diabetes mellitus type II

7) Diabetic ketoacidosis, diabetes mellitus type I

8) Dysliproproteinemia

9) Risk factors of atheroslerosis (of coronary heart disease)

10) Biochemical markers of acute myocardial infarction

11) Porphyria – laboratory investigation

12) Laboratory investigation of sexual hormones (puberty and menopause)

13) Acute renal failure

14) Serology of infectious hepatitis A, B, C

15) Disorders of iron metabolism

16) Gluten enteropathy, malabsorption, malnutrition

17) Biochemical investigation in gastroenterology

18) Disseminated intravascular coagulopathy

19) Monitoring of anticoagulant therapy

20) Urolithiasis (renal stones)

21) Chronic renal insufficiency

22) Creatinine clearance, cystatin C, glomerular filtration

23) Proteinuria

24) Liver cirrhosis

25) Hyperbilirubinemia

26) Albumin, prealbumin, nutrition markers, trace elements

27) Liver tests

28) Monoclonal gamapathy

29) Metabolic acidosis, RTA

30) Metabolic alkalosis

31) Acute and chronic respiratory acidosis and respiratory alkalosis

32) Hypernatremia, hyponatremia, diabetes insipidus

33) Therapeutic drug monitoring

34) Dehydration, hyperhydration, natriuretic peptides

35) Investigation of lactate and ammonia

36) Hormones of adrenal gland

37) Laboratory investigation of bone metabolism

38) Renal and prerenal hyperuremia

39) Laboratory investigation of pancreas

40) Preanalytical phase of laboratory investigation

Last update: Čechová Jana, Mgr. (26.11.2019)
Syllabus

Biological variability

Preanalytical phase

Diabetes mellitus

Lipoproteins

Cardiac markers

Tumor markers

Visit to the laboratory

Bilirubin, liver tests

Thyroid gland tests

Practical application of pharmacokinetic and pharmacodynamic principles

Renal function tests

Acid-base data

Blood gases

Last update: Vyšatová Ivana (07.09.2016)
 
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