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The subject of Histology and Embryology II is intended only for ISP students who repeat it in the second year and have it included in the second year of this divided year.
The course provides students with basic knowledge of microscopic anatomy, special histologic techniques, special embryology, and developmental biology.
Last update: Uhlík Jiří, MUDr., Ph.D. (21.09.2018)
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Conditions for awarding the credit in Histology and Embryology
1. Compulsory presence at practical trainings. Students attend practical trainings according to the time schedule. There is an exceptional possibility to attend a practical training of the same topic with another group, if the classroom capacity is sufficient. One absence per semester is tolerated without any compensation; casual second and further absences can be compensated by an oral examination in missed topics. The date of this examination can be arranged with a teacher individually anytime during the semester. The student, who doesn’t ask for this examination or fails, will have one more chance at the date given during the examination period. Concerning absences, please give your attention to the dean’s provision No. 1/2011 as well.
2. Sitting for the computer credit test at the end of each semester with the result of at least 70 % of correct answers. The student, who fails the test or doesn’t sit for it at the regular date, will have possibility to sit for it at the date given during the examination period.
In the case a student has not fulfilled all the conditions for granting credit even in exceptional dates, will have to demonstrate knowledge of the subject matter at commissional oral examination at the date given by the head of the department. After the failure of this examination, there is no possibility to obtain the credit. More on http://histologie.lf2.cuni.cz/en/teaching/histology/credits Last update: Uhlík Jiří, MUDr., Ph.D. (10.09.2017)
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Compulsory textbooks:
Mescher, A. L.: Junqueira’s Basic Histology. 14th ed., McGraw-Hill, 2016 Sadler, T. W.: Langman's Medical Embryology. 13th ed., Wolters Kluwer, 2015 Nussbaum, R. L et al..: Thompson & Thompson Genetics in Medicine, Chap. 14, 8th ed., Elsevier, 2015
Recommended textbooks: Alberts, B. et al.: Essential Cell Biology. 3rd ed., Garland Publishing, 2009 Pawlina, W (former Ross, M. H., Pawlina, W.): Histology: a Text and Atlas, 7th ed., Wolters Kluwer, 2015 (or older edition) Gartner, L. P., Hiatt, J.L.: Color Atlas and Text of Histology. 6th ed., Lippincott Williams & Wilkins, 2013 Carlson, B. M.: Human Embryology and Developmental Biology. 5th ed., Elsevier, 2014 Slack, J.: Essential Developmental Biology. 3rd ed., Wiley-Blackwell, 2013 Gilbert, S. F.: Developmental Biology. 10th ed., Sinauer, 2014 Pritchard, D. J., Korf, B. R.:Medical Genetics at a Glance. 3rd ed. John Wiley and Sons, 2013 Last update: Uhlík Jiří, MUDr., Ph.D. (04.09.2017)
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The final examination in Histology an Embryology consists of an electronic written test followed with an oral test.
The written test consists of questions in cytology, general histology, microscopic anatomy, histologic methods, general embryology, organogenesis, and developmental biology. Total number of questions is 60. In 59 questions, a candidate chooses one or more correct answer and the correct combination is evaluated by 1 point. One “complex” question consists of 10 sub-questions and is evaluated up to 10 points. Total time for the written test is 70 minutes.
Written test evaluation:
excellent 90 to 100% of correct answers
very good 80 to 89% of correct answers
good 70 to 79% of correct answers
failed less than 70% of correct answers
If a candidate fails by the written test, he/she does not continue with the oral one. On the other hand, having passed the written test and having failed by the oral test a candidate does not repeat the written test.
The oral test consists of two questions. The first question is based on identification and description of a microscopic slide, the second question is based on description of one electron micrograph or embryological schema. All electron micrographs and embryological schemas are available on Moodle in time. The level of knowledge and ability to discuss is evaluated for each question in scale excellent – very good – good – failed. If any question is evaluated “failed”, the examination is finished by the result “failed”. If unsuccessful, the whole oral test is repeated (both questions).
Total evaluation of the examination is calculated as an average of three marks.
By the final examination, a candidate is not allowed to use any his/her own aid.
The final exam is evaluated "failed" if a candidate leaves the examination room during the test.
Validation of exams is regulated by the Dean's provision N°. 7/2014. Last update: Uhlík Jiří, MUDr., Ph.D. (10.09.2017)
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Lectures and practical trainings
Circulatory system. General structure of vessels, capillaries, arteries, veins, lymphatic vessels, heart. Lymphoid system. General structure and classification of lymphoid organs, thymus, lymph nodes, spleen, tonsils. Organogenesis of circulatory and lymphatic systems. Development of the heart, arteries and veins, primitive and fetal circulation, circulatory changes at birth, development of lymphoid vessels and organs. Respiratory system. Epithelium lining airways, structures responsible for air conditioning, nasal cavity, pharynx, larynx, trachea, bronchial tree, alveoli, interalveolar septum. Digestive system. General structure of digestive tract, oral cavity, tongue, teeth, oesophagus, stomach, small and large intestine. Glands associated with the digestive tract - salivary glands, pancreas, liver, biliary tract. Organogenesis of digestive and respiratory systems. Development of the face, oral and nasal cavities and teeth, primitive gut and its development, pharyngeal gut, development of glands associated with the digestive tract, development of respiratory organs, stages of the lung development. Urinary system. Structure of kidneys (renal corpuscle, nephrons, collecting tubules and ducts, juxtaglomerular apparatus), urinary passages. Male reproductive system. Structure of testis, spermatogenesis, intratesticular and excretory genital ducts, accessory genital glands, penis. Female reproductive system. Structure of ovary, ovarian follicles, ovulation, corpus luteum, oviduct, uterus, changes in the endometrium during the menstrual cycle, vagina, external genitalia. Organogenesis of urinary and genital systems. Development of the intermediate mesoderm, pronephros, mesonephros, metanephros - permanent kidney, development of urinary passages, development of testes and ovaries, development of male and female genital ducts, development of external genitalia. Endocrine system. Hypophysis (adenohypophysis, neurohypophysis), pineal gland, thyroid, parathyroid glands, adrenal cortex, adrenal medulla. Nervous system. Central and peripheral nervous system, grey and white matter, spinal cord, cerebellum, cerebrum, meninges, choroid plexus, peripheral nerves, nerve ganglia. Organogenesis of nervous and endocrine systems. Neurulation, histogenesis of the neural tube, primitive brain vesicles, development of the spinal cord and brain, development of the peripheral nerves, development of the endocrine organs. Skin. Epidermis, keratinization, melanocytes and pigment formation, dermis, skin adnexes (hair, nails, glands of the skin), mammary gland. Organogenesis of skin. Developmental stages of the skin, development of skin adnexes and derivatives. Sensory organs. Classification of sensory organs receptors. Somatic and visceral receptors. Structure of eye (fibrous, vascular and nervous layers, lens, vitreous body, accessory structures of eye). Chemoreceptors (olfactory epithelium, taste buds). Audioreceptors (structure of ear, external, middle and internal ear). Proprioceptors. Organogenesis of sensory organs. Development of the eye and ear, development of the olfactory epithelium. Special histological techniques. Histochemistry, immunohistochemistry, lectin histochemistry, fluorescence microscopy, in situ hybridization, scanning electron microscopy, atomic force microscopy (AFM). Embryonic cloning. Stem cells, therapeutic cloning, transgenic organisms, knockout and knockin. Regulative and mosaic development. Preimplantation diagnosis. Stem cells. Characteristic and cultivation of stem cells. Cell therapy, regenerative medicine and its perspectives. Biology of aging. Longevity. Genetic nature of aging, genes controlling aging. Mitochondrial interaction. Diet restriction. Free radicals. Developmental biology and human diseases. Last update: Uhlík Jiří, MUDr., Ph.D. (25.12.2017)
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