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The subject Infection and tropical medicine is addressed to students of general medicine, 5th year.
Students learn pathogenesis, clinical presentation, diagnostics, differential diagnosis and principles of therapy of infectious diseases. The spectrum of diseases follows the actual needs of the subject in the Czech Republic.
Last update: Kubánek Ondřej (30.04.2013)
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The primary goal is to teach students to diferentiate infectious diseases, to diagnose them and adopt the principles of treatment. The secondary goal is to understand relations between microorganisms and human beeings, to be aware of the global aspect of infectious diseases, to understand the specific position of antibiotic (antiinfection) therapy among other therapeutic modalities.
Last update: Kubánek Ondřej (30.04.2013)
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presentations from the seminars available in Výuka Hobstova J (ed.): Infectious Diseases. 2nd ed. Charles University in Prague, Karolinum Press 2012
For microbiology knowledge augmentation, any of the following: Murray P, Rosenthal KS, Pfaller MA. Medical Microbiology, 8th ed., Elsevier Mosby 2015 Goering R, Dockrell H, Zuckerman M, Chiodini P. Mims' Medical Microbiology and Immunology. https://www.elsevier.com/books/mims-medical-microbiology-and-immunology/goering/978-0-7020-7154-6 Barer MR, Irving WL. Medical Microbiology. A Guide to Microbial Infections: Pathogenesis, Immunity, Laboratory Investigation and Control . 19th Ed. https://www.us.elsevierhealth.com/medical-microbiology-9780702072000.html Last update: Džupová Olga, doc. MUDr., Ph.D. (25.09.2019)
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Teaching methods:
seminars, bedside training Last update: Kubánek Ondřej (30.04.2013)
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80% attendance at the lessons (minimum 8 days out of the total 10 days, attendance at both the seminars and bedside practice) is required for credit. Upon late arrival beyond 15 minut the attendance will not be recorded. The Credit will be given at the end of the course supposed that the required attendance was fulfilled. Without getting the Credit the student cannot sign up for the exam.
Exam questions for the subject Infectious and geographic medicine, 5th year, revision 2024
Part A (general infectology + organ-oriented approach/problém areas)
1. Physiological microbial flora, its role in the pathogenesis of infectious diseases
2. Sepsis: definition, pathophysiology, diagnostics
3. Acute tonsillopharyngitis
4. Acute stenosing laryngitis and epiglottitis
5. Community-acquired pneumonia
6. Nosocomial pneumonia
7. Purulent infections of the central nervous system
8. Nonpurulent (aseptic) infections of the central nervous system
9. Diarrhoea of infectious origin, incl. imported infections
10. Infections of the skin and connective tissues (joints, bones)
11. Diff. diagnosis of exanthema infections
12. Overview of CNS infections + diff. diagnostics
13. Infectious diseases with paresis
14. Overview of liver infections + diff. diagnostics
15. Diff. diagnosis of lymphadenopathy, mesenteric lymphadenopathy
16. Fever of unknown origin (except imported)
17. Fever in patient returning from tropics
18. Infective endocarditis
19. Urinary tract infections
20. Congenital and perinatal infections
21. Biological weapons (general principles of use; anthrax, variola, botulism)
22. Toxic shock syndrome
23. Healthcare associated infections (signifikance, classification, predisposition, prevention)
24. Catheter-related infections
25. Infections in immunocompromised patients
26. Infections in intravenous drug users and homeless people
27. Microbiological diagnostic methods for direct detection of pathogens
28. Microbiological diagnostic methods for indirect detection of pathogens
Part B (therapy and prevention of infectious diseases)
1. Corticosteroids in infectious diseases
2. Principles of rational antibiotic therapy (antibiotic stewardship)
3. Penicillins Drugs, antibacterial spectrum, indications, doses, administration, adverse effects
4. Cephalosporins, carbapenems Drugs, antibacterial spectrum, indications, administration, adverse effects
5. Vancomycin, clindamycin, linezolid Drugs, antibacterial spectrum, indications, administration, adverse effects
6. Aminoglycosides, colistin Drugs, antibacterial spectrum, indications, administration, adverse effects
7. Quinolones, rifampicin, chloramphenicol Drugs, antibacterial spectrum, indications, administration, adverse effects
8. Macrolides, tetracyclines Drugs, antibacterial spectrum, indications, administration, adverse effects
9. Cotrimoxazol, nitrofurantoin, metronidazol Drugs, antibacterial spectrum, indications, administration, adverse effects
10. Application of antibiotics in special situations Pregnancy, newborns, elderly, patients with severe comorbidities
11. ATB treatment of anaerobic infections
12. ATB treatment of respirátory tract infections
13. ATB treatment of urinary tract infections
14. ATB treatment of skin, bone and joint infections
15. Principles of treatment of CNS infections
16. ATB treatment of hospital-acquired infections caused by resistant bacteria
17. Treatment of fungal infections
18. Treatment of viral infections
19. Indications for therapeutic and prophylactic administration of specific antisera
20. Complex therapy of sepsis
21. Clinical presentation and treatment of dehydration in acute diarhea
22. Principles of treatment of an animal bite injury
23. Basic recommendations for travellers to the tropics and subtropics
24. Mandatory vaccinations
25. Optional vaccinations
Part C (specific infectious diseases)
1. Infections caused by herpes simplex virus (HSV-1, HSV-2) Clinical manifestation, diagnostics, diff. diagnostics, therapy
2. Varicella-zoster virus infections Clinical manifestation, diagnostics, diff. diagnostics, therapy, prevention
3. Infections caused by EBV and CMV Clinical manifestation, diagnostics, diff. diagnostics, therapy
4. Infections caused by enteroviruses Clinical manifestation, diagnostics, diff. diagnostics, therapy
5. Influenza, covid-19 and other viral respiratory tract infections Etiology, clinical manifestation, complications, diagnosis, therapy, prevention
6. Mumps, measles, rubella Etiology, clinical manifestation, complications, diagnosis, therapy, prevention
7. Central European tick-borne meningoencephalitis Etiology, clinical manifestation, diagnosis, therapy, complications, prevention
8. Viral hepatitis A, E Etiology, clinical manifestation, diagnosis, therapy, complications, prevention
9. Viral hepatitis B, C, D Etiology, clinical manifestation, diagnosis, therapy, complications, prevention
10. Streptococcal infections Clinical manifestation, diagnosis, diff. diagnosis, therapy, complications
11. Pneumococcal infections Clinical manifestation, diagnosis, therapy, complications
12. Staphylococcal infections Clinical manifestation, diagnosis, therapy, complications
13. Meningococcal infections Clinical manifestation, diagnosis, therapy, complications, prevention
14. Infections caused by Escherichia coli: intestinal + extraintestinal disease
15. Salmonellosis, campylobacteriosis, shigellosis Etiology, clinical manifestation, diagnosis, diff. diagnosis, therapy, complications
16. Colitis due to Clostridioides difficile Etiology, clinical manifestation, diagnosis, diff. diagnosis, therapy, complications
17. Tularemia, bartonellosis, listeriosis Etiology, clinical manifestation, diagnosis, diff. diagnosis, therapy
18. Diseases caused by neurotoxins (tetanus, botulism) Etiology, clinical manifestation, diagnosis, diff. diagnosis, therapy, complications, prevention
19. Spirochetal infections (Lyme disease, leptospirosis) Etiology, clinical manifestation, diagnosis, diff. diagnosis, therapy, complications
20. Mycoplasma and Chlamydia infections Etiology, clinical manifestation, diagnostics, diff. diagnostics, therapy
21. Fungal infections (Candida, Aspergillus, Cryptococcus) Clinical manifestation, diagnosis, therapy, complications
22. Malaria Etiology, pathogenesis, clinical manifestation, diagnosis, therapy, complications, prevention
23. Toxoplasmosis Etiology, pathogenesis, clinical manifestation, diagnosis, therapy, complications, prevention
24. Intestinal parasitic infections (protozoal, helminthiasis) Etiology, clinical manifestation, diagnosis, therapy, complications
25. HIV infection Etiology, pathogenesis, classification, clinical manifestation, diagnosis, therapy, prevention
26. HIV-associated opportunistic infections. Etiology, clinical manifestation, diagnosis, therapy
27. Tuberculosis, atypical mycobacterioses Etiology, clinical manifestation, diagnosis, therapy, prevention Last update: Džupová Olga, doc. MUDr., Ph.D. (29.09.2025)
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Sepsis Strategy and tactics of antibiotic therapy HIV infection, opportunistic infections Imported infections Influenza, Covid-19 and other respiratory tract infections Hospital-acquired infections Congenital and perinatal infections Liver and biliary tract infections CNS infections Life-threatening infections Exanthema infections Parasitic infections Infections in specific host (immune compromised, IVDU, homeless) Acute diarhea. rehydration and homeostasis recovery Zoonoses Case reports seminar: CNS infections, infections of the spine Case reports seminar: Pneumonia and other respiratory tract infections 3 bedside practices, training of clinical thinking a decision making in practice
Last update: Džupová Olga, doc. MUDr., Ph.D. (24.09.2025)
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