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Last update: VACUS8A3 (11.03.2010)
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Last update: VACUS8A3 (11.03.2010)
The aim of the SRA is to compare effect of baclofen and GABAb allosteric modulators in normal and neuropathic rats, and to find out the effect of interaction of the substances at subanalgesic doses. |
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Last update: VACUS8A3 (11.03.2010)
Kwang Jin Kim 9 Young Wook Yoon. Jin Mo Chung. Comparison of three rodent neuropathic pain models. Exp Brain Res (1997) 113:200-206
Bowery NG. GABAB receptor: a site of therapeutic benefit. Curr Opin Pharmacol. 2006 Feb;6(1):37-43.
M Franek, S Vaculin. Role of GABA B Receptor Agonist Baclofen in Acute Pain Modulation during the Early Postnatal Period. Pharmacology. 2009;84(2):104-10.
M. FRANĚK, Š. VACULÍN, R. ROKYTA. GABAB Receptor Agonist Baclofen Has Non-Specific Antinociceptive Effect in the Model of Peripheral Neuropathy in the Rat. Physiol. Res. 53: 351-355, 2004 |
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Last update: VACUS8A3 (11.03.2010)
individual teaching, experimental work, data evaluation and interpretation, presentation of the results |
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Last update: VACUS8A3 (11.03.2010)
active participation in experimentation (pain threshold measurement, surgical inducing of neuropathic pain, measurement of motor coordination, data evaluation and interpretation, presentation (Student Research Conference) |
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Last update: VACUS8A3 (11.03.2010)
individual plan
winter semestr: design of the experiment, induction of chronic constriction injury, pain threshold evaluation, motor coordination evaluation
summer semestr: data analysis and interpretation, presentation of the results |