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This course offers a comprehensive introduction to stem cells, covering their various types, properties, and
applications in modern medicine. Through a series of engaging lectures led by experienced researchers, you will
explore topics ranging from embryonic, hematopoietic, and other adult tissue stem cells to tissue engineering and
regenerative medicine.
Students will gain insights into:
• The fundamentals of stem cell biology and the unique characteristics of different stem cell types.
• The process of reprogramming cells into induced pluripotent stem cells (iPSCs).
• The clinical applications of stem cells in treating diseases and injuries.
• Advances in tissue engineering and the future potential of regenerative therapies.
Course Structure: The course consists of seven lectures:
1. Introduction to Stem Cells (Prof. Emanuel Nečas)
2. Embryonic Stem Cells (Mgr. Kateřina Faltusová, Ph.D.)
3. Mesenchymal Stem Cells (Prof. Marie Hubálek Kalbáčová)
4. Hematopoietic Stem Cells (Mgr. Kateřina Faltusová, Ph.D.)
5. Induced Pluripotent Stem Cells (iPSCs) (Mgr. Petr Páral, Ph.D.)
6. Tissue Engineering (Prof. Marie Hubálek Kalbáčová)
7. Tissue Repair and Regeneration (Ing. Tomáš Heizer)
The course will include asynchronous recorded lectures and live interactive sessions, allowing students to
engage with lecturers and ask questions. A final online test will assess students' knowledge, and successful
participants will receive a graded credit.
Who Should Enroll: This course is ideal for students interested in cell biology, biotechnology, and regenerative
medicine. Whether you're a medical student, a biology enthusiast, or someone curious about the future of
healthcare, this course will equip you with essential knowledge and inspire your interest in cutting-edge medical
research.
Last update: Špácová Marika, DiS. (08.01.2025)
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Learning Outcomes:
By the end of the subject, students should be able to: 1. Understand specific features of stem cells 2. Explain the origins and key properties of embryonic stem cells (ESCs), including their pluripotency and role in early development 3. Differentiate between ESCs and adult stem cells and understand their clinical relevance 4. Identify the key factors that regulate ESC pluripotency and self-renewal 5. Understand methods for isolation and cultivation of ESCs and their applications in research and clinics 6. Understand the difference between ESC and induced pluripotent stem cells (iPSCs) 7. Discuss the ethical considerations surrounding ESC and iPSCs research and their potential therapeutic uses 8. Identify the characteristics of Mesenchymal Stem Cells (MSCs) 9. Identify the localization and origin of MSCs 10. Discuss the application of MSCs in research and clinics 11. Explain the modes of action of MSCs 12. Describe the hierarchical process of haematopoiesis and the role of hematopoietic stem cells (HSCs) in blood cell formation 13. Explain the key characteristics of HSCs, including self-renewal and developmental multipotency 14. Understand the origin and development of HSCs during embryogenesis and their niche in adult bone marrow 15. Understand the key research methods for studying HSCs, such as flow cytometry, cell culture and transplantation assays 16. Discuss the clinical applications of HSC transplantation and associated challenges, including donor compatibility and complications 17. Understand the term Tissue Engineering 18. Explain the aim of using Tissue Engineering 19. Explain the nature (components) of Tissue Engineering 20. Discuss the types of tissues broadly replaceable with tissue engineering constructs 21. Explain the concept of cell reprogramming and its significance in stem cell biology 22. Discuss the discovery of iPSCs and the role of key transcription factors in generating iPSCs 23. Explore the clinical applications of iPSCs in disease modelling, drug development, and regenerative medicine 24. Differentiate between tissue repair and tissue regeneration 25. Explain the role of stem cells and the stem cell niche in tissue repair and regeneration 26. Describe the key phases and cellular processes involved in tissue repair 27. Explore the clinical implications of tissue repair and regeneration, including potential therapeutic applications
Last update: Špácová Marika, DiS. (08.01.2025)
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written exam - online test Last update: Hubálek Kalbáčová Marie, prof. RNDr., Ph.D. (06.12.2024)
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Asynchronous teaching, which will take place in the form of recorded lectures, which are available between April 1 and May 30. 2025. During the last week, students will have access to a final test, upon successful completion of which they will receive 1 ECTS. Last update: Špácová Marika, DiS. (08.01.2025)
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• Basic knowledge of cell biology. Last update: Hubálek Kalbáčová Marie, prof. RNDr., Ph.D. (08.01.2025)
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