Clinical Biochemistry - B80114 (General Medicine - English parallel)

• Title: Clinical Biochemistry
• Guaranteed by: Institute of Medical Biochemistry and Laboratory Diagnostics First Faculty of Medicine Charles University and General University Hospital in Prague (11-00410)
• Faculty: First Faculty of Medicine
• Actual: from 2023
• Semester: winter
• Points: 2
• E-Credits: 2
• Examination process: winter s.:
• Hours per week, examination: winter s.:0/25, C+Ex [HS]
• Extent per academic year: 25 [hours]
• Capacity: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Explanation: odb.as.MUDr Ivan Šebesta,CSc
• Old code: 114
• Guarantor: prof. MUDr. Tomáš Zima, DrSc., MBA
• Comes under: Compulsory for GM 5.y._24/25
• Attributes: Lékařství; Klinický předmět
• Pre-requisite : {Patobiochemie pro ALEK jako prerekvizita}, B83161, B83162

Annotation

Clinical case studies from all medical fields with an emphasis on laboratory tests results. The aim of the subject is to practice the indication and interpretation of laboratory tests. Discussions take place and students will be asked to: a) establishment of diagnosis, b) differential diagnosis, c) suggestion of further investigations, d) suggestion of therapy.

Last update: Kolářová Jana (05.03.2021)

Literature

Obligatory:

• Gaw, Allan. Clinical biochemistry : an illustrated colour text. Edinburgh: Churchill Livingstone/Elsevier, 2013, 187 s. ISBN 978-0-7020-5179-1.
• Rifai, Nader, Horvath, Andrea R. Wittwer, C. (eds.). Clinical chemistry and molecular diagnostics. : Elsevier Books, 2018, 1867 s. ISBN 978-0-323-35921-4.
• BHAGAVAN, N. V. Essentials of Medical Biochemistry With Clinical Cases: Second Edition. : Elsevier, 2015, 752 s. ISBN 0124166873.
• WILLIAMSON, MARY A., SNYDER, L. MICHAEL. Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (Interpretation of Diagnostric Tests). : Wolters Kluwer, 2015, 1288 s. ISBN 978-1451191769.
• FISCHBACH, FRANCES T., FISCHBACH, MARGARET, A. Fischbach's A Manual of Laboratory and Diagnostic Tests. : Wolters Kluwer, 2017, 1224 s. ISBN 978-1496377128.

Last update: Šebesta Ivan, MUDr., CSc. (13.09.2023)

Requirements to the exam

Information for students of study groups: 5051,5052 

- teaching starts on Monday 2nd October 2023 at 8,00 a.m.

- at Kateřinská 32, Inst Med Biochem Lab Dg (ÚLBLD)  ground floor, room No. 1.089.    

All lectures are presented on the Institute website: Přednášky ke stažení - Ústav lékařské biochemie a laboratorní diagnostiky (cuni.cz)     

Questions Clinical biochemistry , 5th year, foreign students :

Proteins in plasma, albumin, total protein
Sodium, potassium, chloride, calcium, phosphate, magnesium
Water homeostasis, effective osmolality and its disorders 

Acid base balance

Monitoring scope in the intensive care

Glucose in blood and urine, ketone bodies, lactate
Tests for diabetes mellitus (oGTT,insulin,C-peptide,GAD Ab,HbA1,AGE and others)
Urinalysis, examination of the urinary sediment
Investigation of the lipid disorders
Assessment of the antioxidants capacity, acute - phase reactants

Iron, transferrin, ferritin

Investigations of the impairment of the hepatocytes

Investigation of the porphyrias

Investigation of the small intestine, function tests in gastroenterology
Screening tests in gastroenterology

Examination in endocrinology
Tumor markers
Trace elements
Investigation of cerebrospinal fluid

 

Preanalytical variables, preparing of the patient, collection of the specimen

Biological influences on the laboratory results

Point of care testing, dry chemistry

Urgent tests
Basic principles of the laboratory techniques, photometry, chromatography, ELISA

Therapeutic drug monitoring, drug screening

Investigation and dif.dg. of the bone diseases

Differential diagnosis  of hyperbilirubinaemia and jaundice
Dif.dg. of acute heart diseases

Metabolic syndrome, dif.dg. of hyper and hypouricaemia
Dif.dg. of pancreas impairment
Assessment of renal function, dif.dg. of renal failure

Dif.dg. of proteinuria

Investigation and dif.dg. of urolithiasis
Screening of congenital defects
Inborn errors of metabolism, basic indications for investigation, phenylketonuria
Cytogenetic analysis and its meaning in different clinical specialities
Laboratory control of anticoagulants treatment

Anemias

Preparation of samples for direct detection of infectious agens

Basic principles of proper use of antibiotics

 

 

Last update: Šebesta Ivan, MUDr., CSc. (13.09.2023)

Education plan

English

Schedule block
Week of the block	Day	From - To	Education type	Theme	Teacher	Files	Note	Hodnocení
4	Monday	08:00 - 09:15	seminar	Toxicology,therapeutic drug monitoring	doc. Ing. Drahomíra Springer, Ph.D.			průměr: 5, hodnoceno: 2x
		09:25 - 11:20	seminar	Organization of teaching (exam terms). The impact of preanalytical variables on quality of laboratory results.Indication and interpretation of laboratory tests. POCT. Metabolic disorders.	MUDr. Ivan Šebesta, CSc.		The seminars will take place at lecture hall of Inst Med Bioch Lab Dg,Kateřinská 32, (Dean´s office building,ground floor,door No.1.089) on : 30st OSEptember- 4th October 2024 (1st week of teaching) for study groups 5051+5052; 14th - 18th October 2024 for 5053+5054 . Clinical case studies with emphasis on laboratory tests results will be presented. Students will be asked for a ) establishment of diagnosis, b) differential diagnosis, c) suggestion of further investigations , d) suggestion of therapy	průměr: 5, hodnoceno: 3x
		11:30 - 13:00	seminar	Tumor markers. Interpretation of results with psychosomatic overlap.	prof. MUDr. Marta Kalousová, Ph.D.
	Tuesday	08:00 - 09:00	seminar	Cerebrospinal fluid	prof. MUDr. Marta Kalousová, Ph.D.
		09:05 - 10:30	seminar	Inborn errors of metabolism.	doc. RNDr. MUDr. Pavel Ješina, Ph.D.			průměr: 5, hodnoceno: 1x
		10:35 - 13:00	seminar	Gastroenterology	MUDr. Petr Kocna, CSc.
	Wednesday	08:00 - 09:45	seminar	Hepatology.	prof. MUDr. Libor Vítek, Ph.D.
		09:50 - 11:15	seminar	Hematology.	doc. MUDr. Tomáš Kvasnička, CSc.
		11:20 - 13:00	seminar	Diabetes mellitus,Endocrinology,osteology	MUDr. Zdislava Vaníčková
	Thursday	08:00 - 10:00	seminar	Acid base balance.Hydration,osmolality.			The teacher is: Svobodova,MD
		10:15 - 12:00	seminar	Monitoring scope in the intensive care.	doc. MUDr. Helena Lahoda Brodská, Ph.D.
		12:05 - 13:00	seminar	Microbiology.			The teacher is: MUDr.Adámková,Ph.D.
	Friday	08:00 - 09:00	seminar	Screening of inborn defects.	doc. Ing. Drahomíra Springer, Ph.D.
		09:15 - 10:15	seminar	Classical and oncological genetics.			The teacher is : RNDr.Lizcová,Ph.D.
		10:30 - 12:15	seminar	Nephrology,inflammation,oxidative stress.	prof. MUDr. Tomáš Zima, DrSc., MBA		This seminar also teaches: prof.MUDr.M.Kalousová,Ph.D. Course-unit credit - Dr.I.Šebesta,Ph.D.

Czech

Rozpis blokový
Týden bloku	Den	Od - Do	Typ výuky	Téma	Učitel	Soubory	Poznámka	Hodnocení
4	Pondělí	08:00 - 09:15	seminář	Toxicology,therapeutic drug monitoring	doc. Ing. Drahomíra Springer, Ph.D.			průměr: 5, hodnoceno: 2x
		09:25 - 11:20	seminář	Organization of teaching (exam terms). The impact of preanalytical variables on quality of laboratory results.Indication and interpretation of laboratory tests. POCT. Metabolic disorders.	MUDr. Ivan Šebesta, CSc.		The seminars will take place at lecture hall of Inst Med Bioch Lab Dg,Kateřinská 32, (Dean´s office building,ground floor,door No.1.089) on : 30st OSEptember- 4th October 2024 (1st week of teaching) for study groups 5051+5052; 14th - 18th October 2024 for 5053+5054 . Clinical case studies with emphasis on laboratory tests results will be presented. Students will be asked for a ) establishment of diagnosis, b) differential diagnosis, c) suggestion of further investigations , d) suggestion of therapy	průměr: 5, hodnoceno: 3x
		11:30 - 13:00	seminář	Tumor markers. Interpretation of results with psychosomatic overlap.	prof. MUDr. Marta Kalousová, Ph.D.
	Úterý	08:00 - 09:00	seminář	Cerebrospinal fluid	prof. MUDr. Marta Kalousová, Ph.D.
		09:05 - 10:30	seminář	Inborn errors of metabolism.	doc. RNDr. MUDr. Pavel Ješina, Ph.D.			průměr: 5, hodnoceno: 1x
		10:35 - 13:00	seminář	Gastroenterology	MUDr. Petr Kocna, CSc.
	Středa	08:00 - 09:45	seminář	Hepatology.	prof. MUDr. Libor Vítek, Ph.D.
		09:50 - 11:15	seminář	Hematology.	doc. MUDr. Tomáš Kvasnička, CSc.
		11:20 - 13:00	seminář	Diabetes mellitus,Endocrinology,osteology	MUDr. Zdislava Vaníčková
	Čtvrtek	08:00 - 10:00	seminář	Acid base balance.Hydration,osmolality.			The teacher is: Svobodova,MD
		10:15 - 12:00	seminář	Monitoring scope in the intensive care.	doc. MUDr. Helena Lahoda Brodská, Ph.D.
		12:05 - 13:00	seminář	Microbiology.			The teacher is: MUDr.Adámková,Ph.D.
	Pátek	08:00 - 09:00	seminář	Screening of inborn defects.	doc. Ing. Drahomíra Springer, Ph.D.
		09:15 - 10:15	seminář	Classical and oncological genetics.			The teacher is : RNDr.Lizcová,Ph.D.
		10:30 - 12:15	seminář	Nephrology,inflammation,oxidative stress.	prof. MUDr. Tomáš Zima, DrSc., MBA		This seminar also teaches: prof.MUDr.M.Kalousová,Ph.D. Course-unit credit - Dr.I.Šebesta,Ph.D.