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Course, academic year 2023/2024
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Occupational Medicine and Toxicology - B80113 (General Medicine AP)
Title: Occupational Medicine and Toxicology
Guaranteed by: Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital in Prague (11-00560)
Faculty: First Faculty of Medicine
Actual: from 2023
Semester: winter
Points: 2
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:0/25, C+Ex [HS]
Extent per academic year: 25 [hours]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: Assoc. Prof. Sergej Zacharov, MD, PhD.White uniforms, stethoscopes
Additional information: http://nempov.lf1.cuni.cz/
Old code: 113
Guarantor: prof. MUDr. Sergej Zacharov, Ph.D.
Comes under: Compulsory for GM 4.y._23/24
Attributes: Lékařství
Klinický předmět
Pre-requisite : B80632, B83161, B83162
Annotation -
Last update: prof. MUDr. Daniela Pelclová, CSc. (12.06.2008)
Legal aspects of occupational medicine, prevention of occupational diseases, occupational pneumology, occupational neurology, occupational carcinogens, occupational diseases due to vibrations and overload of extremities. Clinical and occupational toxicology and damage caused by ionizing radiation. Occupational health services.
Aim of the course -
Last update: prof. MUDr. Daniela Pelclová, CSc. (12.06.2008)

In order to prevent and recognize occupational diseases, medical students learn the potentially causal relationships between job and disease in an interesting, patient oriented way. The also learn the basics of occupational and clinical toxicology.

Syllabus
Last update: prof. MUDr. Daniela Pelclová, CSc. (16.05.2019)

Occupational diseases, Czech List of Occupational Diseases, European Schedule of Occupational Diseases, legislation.

Most frequent occupational diseases in Czech Republic, duties of physicians concerning suspection of the occupational origin of a disease, notification, social and economic impact. Endangerment by an occupational disease.

Occupational preventive care. Monitoring of the exposure to noxae in the occupational environment, biological exposure tests, preventive examinations of workers.

First aid in acute intoxications.

Intoxications with illegal drugs.

Antidotes for intoxications.

Intoxications:

* hydrogen cyanide and cyanides

* organic solvents (benzene, toluene, trichlorethylene, perchloroethylene, carbon tetrachloride, chloroform, ethylalcohol, methanol,

gasoline, etyleneglycol)

* pharmaceuticals (benzodiazepins and morphine, tricyclic antidepressants, paracetamol)

* metals (lead and its compounds, mercury and its compounds)

* pesticides (organophosphates, carbamates, rodenticides)

* carbon monoxide

* methemoglobinizing compounds

* mushrooms

* damage by acids and alkalis

Occupational respiratory diseases:

* occupational allergic diseases (allergic rhinitis, asthma, allergic skin diseases)

* occupational interstitial fibroses (asbestosis, extrinsic allergic alveolitis)

* silicosis and coal worker´s pneumoconiosis

* COPD due to black coal

* diseases due to asbestos (benign diseases and tumours)

* acute damage of the airways and lungs due to irritant gases, vapours and dusts

Occupational damage of the peripheral nerves (toxic, due to overload, vibrations-induced)

Disease due to vibrations

Diseases due to overload of upper extremities

Occupational carcinogens (chemical and physical), classification of carcinogens by IARC. Most common occupational carcinogens and their target organs.

Deterministic (non-stochastic) effects of ionizing radiation.
Literature -
Last update: prof. MUDr. Daniela Pelclová, CSc. (16.05.2019)

LaDou J.: Occupational Medicine, 5th Edition, Appleton & Lange 2014.
Olson K.R.: Poisoning and drug overdose. 7th Edition, McGraw-Hill Comp., Inc. 2018.
Teaching methods -
Last update: prof. MUDr. Daniela Pelclová, CSc. (16.05.2019)

Seminars, examination of patients, presentation of laboratory methods, reading of radiological findings, discussion groups, test.
Entry requirements -
Last update: prof. MUDr. Daniela Pelclová, CSc. (16.05.2019)

Pathology, pathophysiology, internal propedeutics.
Requirements to the exam -
Last update: prof. MUDr. Daniela Pelclová, CSc. (13.11.2019)

The date of examination cannot be earlier than the last date of the course. Attendance at all days of the course and successful final test are the mandatory preconditions for examination which will be checked before the examination.

In case of the planned/unplanned absence at certain hours during the course due to objective reasons (disease etc.) please contact the Head of the department by email sergej.zacharov@lf1.cuni.cz to consult the further steps.  

 

Occupational Medicine and Toxicology, Questions

1.

Occupational allergic rhinitis.

Intoxication with cyanides.

2.

Extrinsic allergic alveolitis (chronic form).

Antidotes for intoxications.

3.

Coal worker's pneumoconiosis.

Intoxication with paracetamol, benzodiazepines, morphine, antidepressants (tricyclic, SSRI).

4.

Diseases due to asbestos (non-malignant and malignant).

Intoxication with ethanol, ethylene glycol and methyl alcohol.

5.

Deterministic effects of ionizing radiation (acute radiation syndrome, dermatitis, cataract, sterility).

Acids and alkalis, first aid after ingestion and contamination of the skin and the eyes.

6.

Intoxication with pesticides (organophosphates, carbamates, rodenticides).

Occupational diseases. Definition, list of occupational diseases, legislation, compensation, socio-legal aspects.

7.

Intoxication with organic solvents (general symptoms, toluene, trichloroethylene, perchloroethylene, gasoline).

Occupational preventive care. Preventive examinations of workers performing hazardous jobs.

8.

Intoxications with organic solvents (general symptoms, benzene, carbon tetrachloride, chloroform).

Diseases due to physical overload of extremities.

9.

Intoxication with carbon monoxide.

Hallucinogens: psychedelics (classical hallucinogens), deliriants, dissociatives. Mechanism, psychological and physiological effects, toxicity, treatment

10.

Endangerment by occupational disease, legislation, socio-legal aspects. Biological exposure tests.

Intoxication with mushrooms (A. phalloides, A. pantherina, Psilocybe, Cortinarius).

11.

Occupational peripheral neuropathy (toxic - carbon disulfide, methylalcohol; due to overload, due to vibrations).

Recreational drugs. Sympatomimetic toxidrome. Serotonin syndrome.

12.

Diseases due to vibrations.

Intoxication with mercury, health risks, prevention.

13.

Intoxication with lead, health risks, prevention.

Occupational skin diseases (allergic and non-allergic), diagnostics and management.

14.

Acute damage of the airways and lungs due to irritants (chlorine, nitrogen oxides, gasoline, metals).

Intoxication with methemoglobinizing chemicals.

15.

Extrinsic allergic alveolitis (acute form).

Occupational cancer (chemical, physical, IARC classification).

16.

Occupational asthma.

Noise-induced hearing loss.

17.

First aid in acute intoxications, indication and contra-indications of charcoal. Material Safety Data sheets. Toxicological information Centre.

Benign pneumoconiosis - welder´s lung. Metal fume fever.

18.

Silicosis.

Contamination with radionuclides. Diagnostics, external decontamination of patients, personal protective equipment, treatment.
Education plan -
Schedule block
Week of the block Day From - To Education type Theme Teacher Files Note Hodnocení
0Monday08:00 - 08:45internshipOccupational medicine, socio-legal aspects. prof. MUDr. Daniela Pelclová, CSc. 
08:55 - 09:40internshipGroup B: Toxicological Information Centre. Material safety datasheets. EAPCCT.  
08:55 - 09:40internshipGroup A: Neurological occupational diseases. EMG examination MUDr. Petr Klepiš 
09:55 - 10:40internshipGroup A: Toxicological Information Centre. Material safety datasheets. EAPCCT.  
09:55 - 10:40internshipGroup B: Neurological occupational diseases. EMG examination MUDr. Petr Klepiš 
10:50 - 11:35internshipOccupational rhinitis and asthma. MUDr. Pavlína Klusáčková, Ph.D. 
11:40 - 12:25internshipPneumoconioses, silica, asbestos prof. MUDr. Daniela Pelclová, CSc. 
Tuesday08:00 - 08:45internshipOccupational skin disorders. MUDr. Alena Machovcová, MBA, Ph.D. 
08:55 - 09:40internshipOccupational preventive examinations. Occupational health support  
09:55 - 10:40internshipGroup B: Radiographs of pneumoconioses, ILO classification. MUDr. Pavlína Klusáčková, Ph.D. 
09:55 - 10:40internshipGroup A: Occupational health care in general practitioner office  
10:50 - 11:35internshipGroup B: Occupational health care in general practitioner office  
10:50 - 11:35internshipGroup B: Radiographs of pneumoconioses, ILO classification. MUDr. Pavlína Klusáčková, Ph.D. 
11:40 - 12:25internshipPoisonings with pharmaceuticals and mushrooms. prof. MUDr. Daniela Pelclová, CSc. 
Wednesday08:00 - 08:45internshipHeavy metals. Lead. Mercury. prof. MUDr. Daniela Pelclová, CSc. 
08:55 - 09:40internshipCyanides, methemoglobinizing agents, carbon monoxide. prof. MUDr. Daniela Pelclová, CSc. 
09:55 - 10:40internshipGroup A: Toxicological Information Centre. Material safety datasheets. EAPCCT.  
09:55 - 10:40internshipGroup B: Practical case studies, first aid and antidotes in poisonings  
10:50 - 11:35internshipGroup A: Practical case studies, first aid and antidotes in poisonings  
10:50 - 11:35internshipGroup B: Toxicological Information Centre. Material safety datasheets. EAPCCT.  
11:40 - 12:25internshipOccupational cancer. prof. MUDr. Daniela Pelclová, CSc. 
Thursday08:00 - 08:45internshipDamage due to ionizing radiation. prof. MUDr. Sergej Zacharov, Ph.D. 
08:55 - 09:40internshipGroup A: Spirometry, lung functions, rhinomanometry, FeNO MUDr. Pavlína Klusáčková, Ph.D. 
08:55 - 09:40internshipGroup B: Occupational history. EXAMINATION OF A PATIENT. MUDr. Kamil Vlček 
09:55 - 10:40internshipGroup A: Occupational history. EXAMINATION OF A PATIENT. MUDr. Kamil Vlček 
09:55 - 10:40internshipGroup B: Spirometry, lung functions, rhinomanometry, FeNO MUDr. Pavlína Klusáčková, Ph.D. 
10:50 - 11:35internshipDISCUSSION ON PATIENTS´ EXAMINATION MUDr. Pavlína Klusáčková, Ph.D. 
11:40 - 12:25internshipPoisonings with organic solvents, including alcohols and glycols. prof. MUDr. Sergej Zacharov, Ph.D. 
Friday08:00 - 08:45internshipOccupational rhinitis and asthma. MUDr. Pavlína Klusáčková, Ph.D. 
08:55 - 09:40internshipAcute inhalation injury. Extrinsic allergic alveolitis. MUDr. Pavlína Klusáčková, Ph.D. 
09:55 - 10:40internshipDamage to physical overload, vibrations and noiseMUDr. Jiří Lešovský 
10:50 - 11:35internshipToxicity of recreational drugs. prof. MUDr. Sergej Zacharov, Ph.D. 
11:40 - 12:25internshipIntroduction to test in ROGO prof. MUDr. Sergej Zacharov, Ph.D. 
průměr: 5, hodnoceno: 2x
 
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