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Pathophysiology is a bridge between theoretical medical subjects and clinical studies. Pathophysiology studies changes in the human body as influenced by various diseases. It collects data regarding the causes of various diseases and data regarding the functional changes occurring in various organs systems, organs, tissues and cells. The course of the pathological physiology consists from lectures and seminars. Students are motivated to actively participate in the teaching during seminars and some home work with the aim to prepare them for continuous studies of pathophysiology during their clinical studies and as a part of the continuous medical education. The two semester course deals with pathophysiology of different organ systems of the body, roughly corresponding to clinical specialization, particularly in the internal medicine. General mechanism causing and underlying diseases are included into the teaching curriculum.
Last update: Korhoňová Radmila (01.12.2010)
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Kaufman Ch. E., McKee P. A.: Essentials of Pathophysiology, Little, Brown & Co., Boston, 1996 McPhee et al: Pathophysiology of Disease, Prentice-Hall Int. Kuba, Kubová: Pathophysiology. Univerzita Karlova, 2006 Silbernagl, Lang: Color Atlas of Pathophysiology, Thieme Last update: Korhoňová Radmila (02.12.2010)
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Detail information about seminars, lectures, credit requirments, and exam are on the webside: https://patofyziologie.lf1.cuni.cz/en/information-of-general-medicime The required extent of knowledge for the final exam is determined by the textbook, the content of lectures and seminars, and the list of exam questions. Exam information and questions are at: https://patofyziologie.lf1.cuni.cz/en/information-of-exam For further informations you may contact: radmila.korhonova@lf1.cuni.cz Last update: Korhoňová Radmila (24.05.2019)
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Lectures // Introduction. History of pathophysiology. Health and disease. Organ, cellular and molecular level of etiopathogenesis of the disease. Haematopoiesis and its regulation, failure of haematopoiesis, leukemogenesis Anemias I Anemias II and polycythemias. Myeloproliferative disease: CML, AML, myelodysplastic syndromes Lymphoproliferative disease: lymphomas, CLL, plasmocytoma and amyloidosis Immunohematology, pathophysiological aspects of blood transfusion, stem cell and bone marrow transplantation DISORDER OF CIRCULATORY SYSTEM. Disorders of blood pressure, their causes and consequences Role of physiological regulation in pathophysiology of cardiovascular disease and in general Heart insufficiency and heart failure. Congenital heart disease and valvular disease. Kardiomyopathies; Atherosclerosis. Ischemic heart disease, angina, myocardial infarction. Arrhytmias. DISORDERS OF THE RESPIRATORY SYSTEM. Respiratory insuficiency, ARDS. Disturbances of ventilation mechanics - obstruction and restriction lung disease. Lung fibrosis. Pathogenesis of asthma and COPD. Disorders of ventilation perfusion matching in lungs. Hypoxia. Pathophysiological basis of oxygenotherapy. Disorders of the acid-base chemistry, influence of respiration, lungs and altered metabolism RENAL DISEASE. Tubular and glomerular disorders. Acute renal failure Chronic renal insufficiency and failure. Nephritic and nephrotic syndrome. Tubular disorders. Disturbances of water and mineral balance. Edemas. DISORDERS OF THE GASTROINTESTINAL SYSTEM. Oral cavity and oesophagus, dysphagias, gastroesophageal reflux Disorders of the gastric secretion and function, gastroesophageal reflux Malabsorption syndromes, disorders of small and large intestines. // Seminars: // Introduction, organisational information, (diagnostic methods in hematology) Diagnostic approaches in hematology - pathophysiological aspects Examination of blood clotting - pathophysiological aspects block seminar I (A, B or C) Diagnostic approaches in cardiology I - haemodynamics Diagnostic approaches in cardiology II - ECG Diagnostic approaches in cardiology III - arrhythmias Pathophysiological interpretion of ECG curves and case studies Diagnostic approaches in respiratory disease Diagnostic approaches in renal disease - pathophysiological aspects Examination of the internal environment - water and ions block seminar III (A, B or C) Credit, presentation animal models in pathophysiology/ excurtion of interested students // Special seminars: // Block I - Blood disorders Hemorrhagic diatheses and complex disorders of hemostasis Thrombophilic disorders Iron, sideropenic anemia, iron overload
Block II - Circulatory system disorders Pathophysiology of circulation using simulation models Pathophysiology of shock and circulatory failure Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction
Block III - Respiratory system, internal environment Pathophysiology of respiration using simulation models Cystic fibrosis, immunology of bronchial obstruction Disorders of the internal environment - acid-base chemistry
Last update: Korhoňová Radmila (03.12.2010)
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