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Last update: doc. RNDr. Petr Folk, CSc. (06.07.2021)
Protein-protein and protein-DNA interactions play central roles in signal and energy transduction within the cell. In the first part, the course reviews principal signaling pathways such as calcium and phospholipid signaling, trimeric G-protein coupled signaling, MAPK cascades, or growth factor receptor signaling, among others. In the second and main part, important classes of regulatory proteins are presented in more detail, illustrating the structure-function relationship, significance for oncogenesis, and latest advancements in the field. Major topics: Protein serine kinases, protein tyrosine kinases, lipid kinases, phospholipases, adenylate and guanylate cyclases, protein domains important in signaling, growth factor and cytokine receptors, adaptor proteins, small G proteins, MAPK cascades, focal adhesion signaling, important classes of transcription factors and their modes of regulation, coactivators of transcription factors, complexes for modification and remodeling of chromatin, preinitiation complex of RNAPolII, nuclear structure and gene expression. |
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Last update: doc. RNDr. Petr Folk, CSc. (06.07.2021)
General overview of cell signaling and basic principles: Molecular Biology of the Cell, 6th. Edition, 2014, Bruce Alberts, Alexander D. Johnson, et al. Molecular Cell Biology, 7th. Edition, 2013, Harvey Lodish, Arnold Berk, et al. Chapters 11, 13, 14, 15, 21, 23 Alternatively, use newer edition of any recognized international textbook on cell and molecular biology, biochemistry or molecular physiology. Cell signaling textbooks: Biochemistry of Signal Transduction and Regulation, Viley, 2014, G. Kraus Signal transduction, Academic press, 2015, ljsbrand Kramer Signal Transduction: Principles, Pathways, and Processes, Cold Spring Harbor Laboratory Press, 1st Ed., 2013, Lewis Cantley,Tony Hunter et al. Cellular Signal Processing: An Introduction to the Molecular Mechanisms of Signal Transduction, Taylor & Francis, 2nd Ed., 2017, Friedrich Marks et al. |
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Last update: doc. RNDr. František Půta, CSc. (25.04.2012)
Zkouška je ústní z celého rozsahu přednášené látky. Předpokládány jsou elementární znalosti z biochemie a buněčné biologie. |
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Last update: doc. RNDr. Petr Folk, CSc. (06.07.2021)
Key characteristics of cellular signaling networks are explained at the beginning of the course (1.-15.) and illustrated on the examples covered in subsequent lectures (A.-I.). 1. Receptors couple ligand-binding and effector specificity
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