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Last update: T_UCJF (21.05.2001)
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Last update: doc. Mgr. Milan Krtička, Ph.D. (10.06.2019)
Složení ústní zkoušky. |
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Last update: doc. Mgr. Milan Krtička, Ph.D. (14.01.2019)
Nias A.H.W.: An introduction to radiobiology, Wiley, Chichester, 2000 Alpen E.L.: Radiation Biophysics, Academic Press, San Diego, 1998 Lehnert, S.: Biomolecular action of ionizing radiation, Taylor&Francis, 2008 Mozumder, A.: Fundamentals of Radiation Chemistry, Academic Press, San Diego, 1999 Mozumder, A., Hatano, Y. Charged particle and photon interactions with matter: Chemical, Physicochemical, and Biological Consequences with Applications, Marcel Dekker Inc, 2004 Steel, G.G.: Basic Clinical Radiobiology, 5th Edition, Michael C. Joiner, Albert J. van der Kogel, CRC Press, 2018 Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D.: Molecular Biology of the Cell, Garland Publ., NY 1994 Eric J. Hall, Amato J. Giaccia, Radiobiology for the Radiologist Eighth, North American Edition, 2018 Původní publikace v odborných časopisech od 1990
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Last update: doc. Mgr. Milan Krtička, Ph.D. (10.06.2019)
Požadavky ke zkoušce odpovídají sylabu předmětu v rozsahu prezentovaném na přednášce. |
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Last update: T_UCJF (28.05.2003)
Basic characteristics of radiobiological mechanism in cells and tissues. Attempts of modeling it mathematically in the past century. Survival curves and factors influencing radiobiological mechanism; especially oxygen enhancement ratio. Individual phases of the given mechanism: physical, chemical and biological; and corresponding model chain. Microdosimetric characteristics and radiation energy transfer to the medium; influence of different radiomodificators; final radiobiological effect (cell inactivation and other consequences). Cumulative effect in the irradiated tissue; radiotherapy of tumors. Radiobiological mechanism in cells; double-strand breaks of chromosomal DNA. Detailed shape of survival curves; importance for optimization of radiotherapy approaches and radiation hygiene (including protection of astronauts). Application of different kinds of ionizing particles in tumor radiotherapy; hadrontherapy. |