Design and synthesis of compounds with potential antifungal activity

• Thesis title in Czech: Návrh a příprava látek s potenciální antifungální aktivitou
• Thesis title in English: Design and synthesis of compounds with potential antifungal activity
• Key words: antifungální, inhibitor, syntéza
• English key words: antifungal, inhibitor, synthesis
• Academic year of topic announcement: 2024/2025
• Thesis type: dissertation
• Thesis language: angličtina
• Department: Department of Organic Chemistry (31-270)
• Supervisor: Ing. Ondřej Baszczyňski, Ph.D.
• Author: hidden - assigned and confirmed by the Study Dept.
• Date of registration: 08.10.2024
• Date of assignment: 08.10.2024
• Confirmed by Study dept. on: 11.10.2024

Guidelines

1st year - winter semester: Organic Synthesis I and Scientific Writing
1st year - summer semester: NMR Spectroscopy of Organic Compounds and Organic Chemistry of Biological Processes
other subjects will be suggested according to the situation

References

medicinal chemistry and drugs design related books; top scientific journals e.g. Nature, Science, J. Med. Chem.

Preliminary scope of work

Cílem plánovaného disertačního projektu bude návrh a příprava látek, inhibitorů enzymů esenciálních pro život patogenních hub. Mezi potenciální cíle bude studium inhibitorů acetohydroxyacid syntázy (AHAS), který je prvním enzymem v syntéze rozvětvených aminokyselin. Plánuje se také příprava proléčiv odvozených o známých léčiv za účelem vylepšení jejich farmakokinetických vlastností.

Preliminary scope of work in English

Aim of this PhD project is the design and synthesis of inhibitors targeting essential fungal enzymes, which are crucial for the survival of pathogenic fungi. Acetohydroxyacid synthase, the first enzyme in the synthesis of branched-chain amino acids, will be included among the potential targets. We also plan the synthesis of prodrugs derived from FDA approved compounds to improve their pharmacokinetic profile.