hidden - assigned by the advisor, waiting for guarantor's approval
Date of registration:
19.11.2020
Date of assignment:
24.11.2020
Date of electronic submission:
20.06.2021
Date of proceeded defence:
13.07.2021
Opponents:
PharmDr. Eliška Matoušová, Ph.D.
Guidelines
organická chemie I a II, organická syntéza I
References
Oral Delivery of Propofol with Methoxymethylphosphonic Acid as the Delivery Vehicle, J. Med. Chem. 2017, 60, 20, 8580–8590. Sterically‐Controlled Self‐Immolation in Phosphoramidate Linkers Triggered by Light, Eur. JOC, 2020, 7, 897-906.
Preliminary scope of work
Cílem práce bude syntéza modelových oximů, a oximů odvozených od vybraných léčiv, kterým je například griseofulvin. Tyto oximy budou dále modifikovány připojením fotoaktivovatelné, fosfátové, self-immolativní spojky za účelem studia rozpadu těchto aduktů (studium vyloučení oximového léčiva). Nabyté poznatky budou sloužit k syntéze proléčiv.
Preliminary scope of work in English
Aim of this bachelor thesis will be the synthesis of model oximes, and oximes derived from selected drugs such as griseofulvin. Oximes will be modified by addition of a photocleavable, phosphate, self-immolative linker to study the defragmentation of such constructs (model drug release studies). Knowledge acquired will be used in the synthesis of prodrugs.
- assigned by the advisor, waiting for guarantor's approval