Efluxové systémy v antimikrobní rezistenci Acinetobacter baumannii
| Thesis title in Czech: | Efluxové systémy v antimikrobní rezistenci Acinetobacter baumannii |
|---|---|
| Thesis title in English: | Efflux systems in antimicrobial resistance of Acinetobacter baumannii |
| Key words: | Rezistence, efluxové systémy, Acinetobacter baumannii, RND, AdeABC |
| English key words: | Resistance, efflux systems, Acinetobacter baumannii, RND, AdeABC |
| Academic year of topic announcement: | 2009/2010 |
| Thesis type: | Bachelor's thesis |
| Thesis language: | čeština |
| Department: | Department of Genetics and Microbiology (31-140) |
| Supervisor: | prof. RNDr. Alexandr Nemec, Ph.D., Ph.D. |
| Author: | hidden - assigned by the advisor, waiting for guarantor's approval |
| Date of registration: | 05.10.2009 |
| Date of assignment: | 05.10.2009 |
| Date of electronic submission: | 20.08.2010 |
| Date of proceeded defence: | 14.09.2010 |
| Opponents: | RNDr. Jana Beranová, Ph.D. |
| Preliminary scope of work |
| Acinetobacter baumannii je významný nemocnicní patogen, který zahrnuje kmeny rezistentní k vetšine nebo i všem terapeuticky využitelným antibiotikum. Tato rezistence je výsledkem rady bunecných mechanizmu, mezi nimiž hrají zásadní roli systémy aktivního efluxu antimikrobních látek. Tato práce podává prehled jednotlivých rodin efluxových systému a jejich dosud známých zástupcu u rodu Acinetobacter. Zameruje se na efluxový systém AdeABC náležející do rodiny RND (resistance-nodulation-cell division family). Tento systém je prítomen u vetšiny kmenu A. baumannii a tvorí jej tri strukturní proteiny, jež jsou regulovány dvousložkovým regulacním systémem. Nadprodukce AdeABC zpusobuje rezistenci nebo snížení citlivosti k rade antibiotik a je obvykle spojená s dalšími mechanizmy rezistence. |
| Preliminary scope of work in English |
| Acinetobacter baumannii is an important nosocomial pathogen which includes also strains resistant to majority or all therapeutically relevant drugs. This resistance is a result of the activities of many cellular mechanisms, among which systems of active efflux of antimicrobial agents play an important role. This study describes all main families of bacterial efflux systems and their known representatives described in the genus Acinetobacter. It focuses on the efflux system AdeABC belonging to the RND family (resistance-nodulationcell division family). This system is present in the majority of A. baumannii strains and it is formed by three structural proteins regulated by a two-component system. Overexpression of AdeABC results in resistance or decreased susceptibility to many drugs and is usually associated with other resistance mechanisms. |