Úloha selenu při prevenci rakoviny

• Thesis title in Czech: Úloha selenu při prevenci rakoviny
• Thesis title in English: Selenium as a cancer-protective agent
• Key words: selen, rakovina, ROS, thioredoxin reduktáza, glutathion peroxidáza, seleničitan, selenomethion, klinické testy
• English key words: selenium, cancer, ROS, thioredoxin reductase, glutathion peroxidase, selenite, selenomethionine, clinical trials
• Academic year of topic announcement: 2010/2011
• Thesis type: Bachelor's thesis
• Thesis language: čeština
• Department: Department of Genetics and Microbiology (31-140)
• Supervisor: RNDr. Michaela Schierová, Ph.D.
• Author: hidden - assigned by the advisor, waiting for guarantor's approval
• Date of registration: 27.09.2011
• Date of assignment: 22.12.2011
• Date of electronic submission: 15.05.2012
• Date of proceeded defence: 05.06.2012
• Opponents: RNDr. Hana Španielová, Ph.D.

Preliminary scope of work

Mechanismy působení selenoproteinů a selenosloučenin v organismu.
Chemopreventivní účinky, závislost efektu na koncentraci, rozdíly mezi nádorovými a nenádorovými buňkami.
Apoptóza indukovaná nízkomolekulárními sloučeninami selenu.
Populační studie a jejich kritické hodnocení.

Preliminary scope of work in English

The physiological role of selenoproteins and low molecular weight selenium compounds in human body.
Chemopreventive activity, the dose effect, different response of cancer and non-cancer cells.
Apoptosis induced by low molecular weight selenium compounds.
Population studies and clinical trials, comparison and discussion.