hidden - assigned and confirmed by the Study Dept.
Date of registration:
06.01.2025
Date of assignment:
06.01.2025
Confirmed by Study dept. on:
15.01.2025
Study form:
full-time
Date of electronic submission:
29.04.2025
Date of proceeded defence:
30.05.2025
Opponents:
Josipa Grušanović
Preliminary scope of work
WASH1, též známý pod označením WASHC1, je důležitou složkou pentamerního komplexu WASH (z angl. Wiskott-Aldrich syndrome protein and SCAR Homologue). Tento komplex hraje klíčovou úlohu při napomáhání aktinové polymeraci na různých místech eukaryotní buňky. Práce shrne zásadní interakce WASH1 s jinými proteiny, ať již v rámci WASH komplexu, ale také s dalšími vazebnými partnery, kteří se spolupodílejí na fyziologické roli WASH1 v savčích buňkách.
Preliminary scope of work in English
WASH1, also known as WASHC1, is a critical component of the pentameric WASH complex (Wiskott-Aldrich syndrome protein and SCAR Homologue). This complex plays a pivotal role in facilitating actin polymerization at various subcellular locations. The thesis will provide an overview of WASH1 interactions with other proteins within WASH complex as well as with other interaction partners that contribute to its physiological roles in mammalian cells.
- assigned and confirmed by the Study Dept.