hidden - assigned and confirmed by the Study Dept.
Date of registration:
08.11.2022
Date of assignment:
04.01.2023
Confirmed by Study dept. on:
27.01.2023
Date of electronic submission:
22.08.2025
Advisors:
RNDr. Jakub Tomala, Ph.D.
Preliminary scope of work
Náplní práce bude rekombinantní exprese a charakterizace několika forem fúzního proteinu sestávajícího z interleukinu 2 a monoklonální protilátky proti němu samému s cílem zvýšené vazby na IL-2 receptor, a následné ověřování biologické aktivity připravených proteinů z hlediska aktivace cílené proliferace T lymfocytů, potažmo protinádorové aktivity v myších modelech. Realizováno ve spolupráci s Dr. Jakubem Tomalou (BTÚ AV ČR - BIOCEV).
Preliminary scope of work in English
The aim of the thesis is the recombinant expression of several forms of a fusion protein composed of an interleukin 2 and a monoclonal antibody against IL-2, aiming for increased binding to the IL-2 receptor and subsequent determination of the biological activity of the prepared proteins with respect to activation of the directed proliferation of T lymphocytes or antitumour activity in mouse tumour models. Realized in collaboration with Dr. Jakub Tomala (Institute of Biotechnology - BIOCEV).
- assigned and confirmed by the Study Dept.