Thesis (Selection of subject)Thesis (Selection of subject)(version: 385)
Thesis details
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Regulation of mycobacterial transcription by selected sRNAs and proteins
Thesis title in Czech: Regulace mykobakteriální transkripce pomocí vybraných malých RNA a proteinů
Thesis title in English: Regulation of mycobacterial transcription by selected sRNAs and proteins
Key words: sRNA, Mycobacterium smegmatis, transkripce, CarD
English key words: sRNA, Mycobacterium smegmatis, transcription, CarD
Academic year of topic announcement: 2020/2021
Thesis type: dissertation
Thesis language: angličtina
Department: Department of Genetics and Microbiology (31-140)
Supervisor: Mgr. Jarmila Hnilicová, Ph.D.
Author: hidden - assigned by the advisor
Date of registration: 06.10.2020
Date of assignment: 06.10.2020
Date of electronic submission:19.06.2024
Date of proceeded defence: 13.09.2024
Opponents: RNDr. Jan Nešvera, CSc.
  prof. Mgr. David Staněk, Ph.D.
 
 
Award:Thesis was put forward for an award
Preliminary scope of work
Cílem práce je popsání komplexu malé RNA Ms1 a RNA polymerázy, který se vytváří během stacionární fáze růstu. Student popíše, jaké další proteiny jsou součástí tohoto komplexu. Dále najde proteiny, které regulují vazbu RNA polymerázy na Ms1, a přispěje k objasnění struktury Ms1-RNA polymerázy. Vedle toho se práce bude zabývat dalšími mykobakteriálními transkripčními faktory a jejich rolí ve stacionární fázi růstu.
Preliminary scope of work in English
The aim of this work is to describe the complex of small RNA Ms1 and RNA polymerase, which is formed during the stationary phase of growth. The student will describe other proteins that interact with this complex, proteins that regulate the binding of RNA polymerase to Ms1 and will contribute to the elucidation of Ms1-RNAP structure. In addition, the work will focus on other mycobacterial transcription factors and their roles in the stationary phase of growth.
 
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