Inhibice enzymové aktivity cytochromů P450 endokrinním disruptorem 17α-ethinylestradiolem

• Thesis title in Czech: Inhibice enzymové aktivity cytochromů P450 endokrinním disruptorem 17α-ethinylestradiolem
• Thesis title in English: Inhibition of enzyme activity of cytochromes P450 by endocrine disruptor 17α-ethinylestradiol
• Key words: endokrinní disruptory, 17α-ethinylestradiol, cytochrom P450, inhibice, IC50
• English key words: endocrine disruptors, 17α-ethinylestradiol, cytochrome P450, inhibition, IC50
• Academic year of topic announcement: 2018/2019
• Thesis type: diploma thesis
• Thesis language: čeština
• Department: Department of Biochemistry (31-250)
• Supervisor: RNDr. Helena Dračínská, Ph.D.
• Author: hidden - assigned by the advisor, waiting for guarantor's approval
• Date of registration: 19.11.2018
• Date of assignment: 23.11.2018
• Date of electronic submission: 11.06.2020
• Date of proceeded defence: 15.07.2020
• Opponents: prof. RNDr. Helena Ryšlavá, CSc.

Preliminary scope of work

Studium vlivu 17-α ethinylestradiolu (příp. 17β-estradiolu) na markerové aktivity potkaních a lidských izoforem CYP. Měření enyzmové aktivity, určování typu inhibice enzymové reakce, stanovení inhibiční konstanty.