Mechanismy a vývoj azolové rezistence v sekci Fumigati rodu Aspergillus

• Thesis title in Czech: Mechanismy a vývoj azolové rezistence v sekci Fumigati rodu Aspergillus
• Thesis title in English: Mechanisms and evolution of Aspergillus section Fumigati azole resistance
• Key words: rezistence k antifungálním lékům, triazolová antimykotika, invazivní aspergilóza, mutace, Aspergillus fumigatus
• English key words: antifungal drug resistance, triazole antimycotic, invasive aspergillosis, mutations, Aspergillus fumigatus
• Academic year of topic announcement: 2018/2019
• Thesis type: Bachelor's thesis
• Thesis language: čeština
• Department: Department of Botany (31-120)
• Supervisor: Mgr. František Sklenář, Ph.D.

References

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Preliminary scope of work

Invazivní aspergillóza je jednou z nejčastějších chorob, které způsobují zástupci říše hub. Léčba se nejčastěji provádí pomocí triazolových antimykotik (např. vorikonazol, itrakonazol, posakonazol). Během posledních dvou desetiletí ale dochází k šíření rezistetnce k těmto antimykotikům mezi zástupci druhu Aspergillus fumigatus (který nejčastěji způsobuje infekci) a příbuzných druhů. Studium rezistentních kmenů ukázalo, že ke vzniku rezistence mohou vést různé mutace v cílových genech. Cílem této práce bude shrnout dosavadní poznatky o mechanismech vzniku azolové rezistence a jejím šíření.