Vliv endokrinních disruptorů na expresi a aktivitu cytochromů P450 2B v modelovém organismu potkana

• Thesis title in Czech: Vliv endokrinních disruptorů na expresi a aktivitu cytochromů P450 2B v modelovém organismu potkana
• Thesis title in English: The effects of endocrine disruptors on the expression and the activity of cytochromes P450 2B in laboratory rat as a model organism
• Key words: endokrinní disruptory, benzo[a]pyren, ethinylestradiol, estradiol, cytochrom P450 2B, exprese, aktivita, indukce
• English key words: endocrine disruptors, benzo[a]pyrene, ethinylestradiol, estradiol, cytochrome P450 2B, expression, activity, induction
• Academic year of topic announcement: 2017/2018
• Thesis type: Bachelor's thesis
• Thesis language: čeština
• Department: Department of Biochemistry (31-250)
• Supervisor: RNDr. Helena Dračínská, Ph.D.
• Author: hidden - assigned by the advisor, waiting for guarantor's approval
• Date of registration: 13.11.2017
• Date of assignment: 16.11.2017
• Date of electronic submission: 25.05.2018
• Date of proceeded defence: 12.06.2018
• Opponents: RNDr. Kateřina Levová, Ph.D.

Preliminary scope of work

Studium vlivu endokrinních disruptorů na genovou a proteinovou expresi a aktivitu cytochromů P450 podrodiny 2B v modelovém organismu potkana.
Metody: kvantitativní PCR, Westernblot s následnou imunodetekcí, měření enzymové aktivity