Vliv vandetanibu, lenvatinibu a ellipticinu na expresi potkaních cytochromů P450 1A a 3A
| Thesis title in Czech: | Vliv vandetanibu, lenvatinibu a ellipticinu na expresi potkaních cytochromů P450 1A a 3A |
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| Thesis title in English: | The effect of vandetanib, lenvatinib and ellipticine on the expression of rat cytochromes P450 1A and 3A |
| Key words: | vandetanib, lenvatinib, ellipticin, cytochromy P450, inhibitory tyrosinkinas |
| English key words: | vandetanib, lenvatinib, ellipticine, cytochromes P450, tyrosine kinase inhibitors |
| Academic year of topic announcement: | 2016/2017 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Biochemistry (31-250) |
| Supervisor: | RNDr. Helena Dračínská, Ph.D. |
| Author: | hidden - assigned by the advisor, waiting for guarantor's approval |
| Date of registration: | 18.11.2016 |
| Date of assignment: | 21.11.2016 |
| Date of electronic submission: | 09.05.2018 |
| Date of proceeded defence: | 21.05.2018 |
| Opponents: | RNDr. Lenka Žáková, Ph.D. |
| Preliminary scope of work |
| Studium vlivu protinádorových léčiv - inhibitorů tyrosinkinas vandetanibu a lenvatinibu a cytostatika ellipticinu - na genovou a proteinovou expresi a aktivitu cytochromů P450 podrodin 1A a 3A v modelovém organismu potkana. Metody: izolace mikrosomů, izolace RNA, kvantitativní PCR, Westerblot s následnou imunodetekcí, měření enzymové aktivity... |