Studium stresu v endoplazmatickém retikulu

• Thesis title in Czech: Studium stresu v endoplazmatickém retikulu
• Thesis title in English: Endoplasmic reticulum stress
• Key words: endoplazmatické retikulum, ER, kvasinka Saccharomyces cerevisiae, funkce ER, stres v ER, buněčná odpověď na nesbalené proteiny, UPR, nemoci spojené s ER
• English key words: endoplasmic reticulum, ER, yeast Saccharomyces cerevisiae, ER function, ER stress, unfolded protein response, UPR, ER diseases
• Academic year of topic announcement: 2010/2011
• Thesis type: Bachelor's thesis
• Thesis language: čeština
• Department: Department of Genetics and Microbiology (31-140)
• Supervisor: RNDr. Michaela Schierová, Ph.D.
• Author: hidden - assigned by the advisor, waiting for guarantor's approval
• Date of registration: 27.08.2011
• Date of assignment: 20.12.2011
• Date of electronic submission: 26.08.2012
• Date of proceeded defence: 14.09.2012
• Opponents: RNDr. Lenka Horníková, Ph.D.

Preliminary scope of work

Endoplazmatické retikulum - jeho funkce a morfologie.
Stres v ER a jeho indukce.
Srovnání stresu v ER u kvasinky Saccharomyces cerevisiae a savců.
Mechanismy uvolňující stres v ER.
Metodické přístupy ke studiu ER u kvasinek.

Preliminary scope of work in English

Endoplasmic reticulum, its function and morphology.
Endoplasmic reticulum stress and its inducers.
The comparison of endoplasmic reticulum stress in yeast Saccharomyces cerevisiae and mammals.
The mechanisms releasing ER stress.
Methods for ER function analysis used in yeast.